Results 191 to 200 of about 7,394,141 (337)

Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas.

American Journal of Pathology, 2001
J. Boström, B. Meyer‐Puttlitz, M. Wolter, Britta Blaschke, R. Weber, P. Lichter, K. Ichimura, V. Collins, G. Reifenberger   +8 more
semanticscholar   +1 more source

BCMA Antigen Loss Through Acquired TNFRSF17 Deletion in Multiple Myeloma

International Journal of Laboratory Hematology, EarlyView.
Ali Benaboud, Rémi Tilmont, Gauthier Decool, Nicolas Gower, Salomon Manier, Benjamin Podvin   +5 more
wiley   +1 more source

Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study. [PDF]

EBioMedicine
Lue JC, Stallings-Mann M, Hoskin T, McCauley BM, Vierkant RA, Pacheco-Spann L, Fischer JL, Gehling DL, Seymour LR, Baker DJ, Degnim AC, Winham SJ, Sherman ME, Radisky DC.   +13 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Promoter hypermethylation of multiple genes in hydatidiform mole choriocarcinoma

, 2004
Promoter hypermethylation has been known to be an important pathway for gene inactivation and contributes to the carcinogenesis of many human tumors. Little is currently known about the methylation status of tumor suppressor genes in hydatidiform mole ...
Xue, W, Chan, DY, Feng, H, Tsao, GSW, Ngan, HYS, Chiu, PM, Cheung, ANY   +6 more
core  

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Targeting the senescence‒autophagy axis via p16^INK4a inhibition alleviates pulmonary fibrosis. [PDF]

Signal Transduct Target Ther
Yoo YJ, Zhang M, Jin SH, Lee YR, Jin H, Doan TP, Kim S, Choi S, Park EJ, Na S, Lee Y, Sun J, Cho J, Cho NC, Park SY, Oh WK, Lee YS.   +16 more
europepmc   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

HPV16 E7-Associated SERPINB3 Suppression and MYC-Related Epithelial Plasticity in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Liu Z, Zhang S, Liu T, Li Y, Li R, Liu H, Wang D, Tang Y, Ma H, Zhang Y, Wei L, Chu M.   +11 more
europepmc   +1 more source

Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa

Journal of Cancer Research and Clinical Oncology, 2006
Keizo Kato, A. Hara, T. Kuno, H. Mori, T. Yamashita, M. Toida, T. Shibata   +6 more
semanticscholar   +1 more source