Results 211 to 220 of about 7,394,141 (337)

Secreted protein combination GAPDH/S100A8/S100A9 from human expanded potential stem cells counteracts mesenchymal stromal cell senescence. [PDF]

Stem Cell Res Ther
Feng Q, Pang Q, Lu H, Liu Z, Lin Z, Songyang Z, Liu F, Shi G.   +7 more
europepmc   +1 more source

Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea

Glia, Volume 74, Issue 11, November 2026.
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmanci, Christopher J. Yates, Kenneth Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand, Hyun Kyoung Lee, Benjamin Deneen, Hyun‐Hwan Jeong, Arvind Chandrakantan   +13 more
wiley   +1 more source

HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Measurement of Disease Burden in Oropharyngeal Cancer

International Journal of Cancer, Volume 159, Issue 9, Page 2336-2346, 1 November 2026.
ABSTRACT The incidence of human papillomavirus‐positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly, and HPV early antigen serology has been proposed as a scalable and cost‐effective early detection test. HPV seropositivity can precede clinical presentation of OPC by several years, so additional surveillance procedures may be necessary to ...
Lucas Penny, Eric Yang Stutheit‐Zhao, Birgitta E. Michels, Fabian Rosing, Zhen Zhao, Yangqiao Zheng, Jinfeng Zou, Shao Hui Huang, Johnny Carlton, Andrew McPartlin, John R. de Almeida, David Goldstein, Andrew Hope, Ali Hosni, John Kim, Fei‐Fei Liu, C. Jillian Tsai, John N. Waldron, Anna Spreafico, Enrique Sanz‐Garcia, Lillian L. Siu, Tim Waterboer, Geoffrey Liu, Scott V. Bratman   +23 more
wiley   +1 more source

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors

Oncogene, 1997
H. Kovar, G. Jug, D. Aryee, A. Zoubek, P. Ambros, B. Gruber, R. Windhager, H. Gadner   +7 more
semanticscholar   +1 more source

Productive or Transforming? How Epithelial Compartmentalization of HPV DNA and E6/E7 Transcripts Shapes Cervical Screening Assay Performance

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The human papillomavirus (HPV) life cycle is linked to epithelial cell differentiation, with viral genome amplification, E6/E7 transcription, and virion assembly spatially compartmentalized within the cervical epithelium. This organization is disrupted in transforming lesions.
Konstanze Schichl, John Doorbar
wiley   +1 more source

Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia. [PDF]

Int J Mol Sci
Vazquez-Villaseñor I, Benson B, Richardson CD, Waller R, Castelli LM, Simpson JE, Matthews FE, Brayne C, Wharton SB, CFAS.   +9 more
europepmc   +1 more source

Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models

MedComm, Volume 7, Issue 11, November 2026.
Multiple mechanisms including senescent cell accumulation, metabolic and endotoxin‐driven stimulation of immune and endothelial cells contribute to inflammaging, the chronic low‐grade inflammatory status underlying age‐related diseases. Blocking leptin signaling in experimental models of inflammaging blunts inflammation in a model‐specific manner while
Valeria Pellegrini, Rosalba La Grotta, Alessia Metallo, Francesca Carreras, Chiara Frigé, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Francesca Rispoli, Lorenzo Drago, Cesare Celeste Berra, Raffaele Marfella, Giuseppe Paolisso, Giuseppe Matarese, Claudio Procaccini, Ilaria Spatocco, Giorgia Mele, Paola de Candia, Antonio Ceriello, Francesco Prattichizzo   +20 more
wiley   +1 more source

Characterization of p16-positive stromal cells in age-related cardiac disorders. [PDF]

J Biochem
Morimura T, Wang TW, Kawakami S, Nakanishi M.   +3 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation. [PDF]

PLoS One
Li J, Zhou G, Wang Q, Song Z, Liu J, Shen C, Luo C, Wang D.   +7 more
europepmc   +1 more source