Results 271 to 280 of about 47,513 (307)

Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma

Cancer, 2005
AbstractBACKGROUNDStepwise progression of peripheral‐type lung adenocarcinoma was characterized morphologically and was related to prognosis. Expression of the tumor suppressor gene p16 in pulmonary adenocarcinoma decreased, mainly as a result of aberrant methylation of the CpG islands of the promoter region.METHODSAberrant methylation status of the ...
Ryota, Tanaka, Daye, Wang, Yukio, Morishita, Yukinori, Inadome, Yuko, Minami, Tatsuo, Iijima, Shimao, Fukai, Tomoyuki, Goya, Masayuki, Noguchi   +8 more
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Adenoviral p16/CDKN2 gene transfer to malignant glioma: Role of p16 in growth, invasion, and senescence

Oncology Reports, 2003
In gliomas, a high frequency of homozygous p16 gene deletions have been demonstrated, which are believed to be linked with malignant progression. The aim of this study was to assess the role of p16 in growth, invasion, and senescence. The human glioma cell lines U87 MG and U373 MG were transduced with Ad-p16, and cell viability was assessed by trypan ...
Seung-Ki, Kim, Kyu-Chang, Wang, Byung-Kyu, Cho, Su-Young, Lim, Young-Yim, Kim, Chang-Wan, Oh, You-Nam, Chung, Chae-Yong, Kim, Choon-Taek, Lee, Hyun Jib, Kim   +9 more
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Mutations of the p16 gene product are rare in prostate cancer

The Prostate, 1997
The p16 gene product is a negative regulator of cell cycle and has been shown to be deleted or mutated in a number of tumor cell lines and primary tumors. The role of p16 in prostate cancer is not defined. Prostate cancer tissues and cell lines were evaluated for p16 gene alterations.Five metastatic prostate cancer cell lines were analyzed for p16 gene
J P, Gaddipati, D G, McLeod, I A, Sesterhenn, C J, Hussussian, Y A, Tong, P, Seth, N C, Dracopoli, J W, Moul, S, Srivastava   +8 more
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A systematic review of hypermethylation of p16 gene in esophageal cancer

Cancer Biomarkers, 2013
Background: Inactivation of cell-cycle regulating gene p16, resulting from epigenetic alteration, is common in the carcinogenesis of human cancers. The aim of this study is to offer a systematic review on the aberrant methylation of p16 gene in esophageal cancer. Methods: We performed a meta-analysis referring to the guidelines of PRISMA.
Ruobing, Xu, Fengliang, Wang, Liang, Wu, Jianming, Wang, Cheng, Lu   +4 more
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Deletion analysis of the p16 tumour suppressor gene in phaeochromocytomas

Clinical Endocrinology, 1996
SummaryBACKGROUND AND OBJECTIVES The molecular pathogenesis of phaeochromocytoma has not yet been fully established. The p16 turnour suppressor gene is often inactivated in a wide variety of primary human malignancies, including tumours of ectodermal origin.
R C, Aguiar, P L, Dahia, H, Sill, S P, Toledo, J M, Goldman, N C, Cross   +5 more
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[Effects of inorganic arsenicals on the methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells].

Zhonghua yi xue za zhi, 2002
To study the effects of inorganic arsenicals on the methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells.The methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells were measured by methylation-specific PCR (MSP) and RT-PCR methods.(1) The exposure of the BEP2D cells to sodium arsenite (0.016 ...
G, Lu, Q, Cai, W, Zhang
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Clinical Significance of P16 Gene Methylation in Lung Cancer

2020
Lung cancer is the leading cause of death from cancer in China. The lack of early screening technologies makes most patients to be diagnosed at advanced stages with a poor prognosis which often miss the best treatment opportunities. Thus, identifying biomarkers for minimally invasive detection and prognosis of early stage disease is urgently needed ...
Yanjun, Li, Tingting, Zhang, Hui, Zhang, Xiangdong, Wang, Xiaozhuan, Liu, Qihong, Huang, Li, Li   +6 more
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Mutational analysis of the p15 and p16 genes in acute leukaemias

British Journal of Haematology, 1996
Recently the p16 and related p15 genes have been described as candidate tumour suppressors at chromosome 9p21. These genes have been found to be homozygously deleted at a high frequency in several types of solid tumours and also in acute lymphoid leukaemias.
H, Sill, R C, Aguiar, H, Schmidt, A, Hochhaus, J M, Goldman, N C, Cross   +5 more
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[Hypermethylation of CpG island of p16 gene and arsenic trioxide induced p16 gene demethylation in multiple myeloma].

Zhonghua nei ke za zhi, 2006
To investigate the role of hypermethylation of p16 gene in the pathogenesis of multiple myeloma (MM) and the effect of arsenic trioxide (As2O3) induced p16 gene demethylation.Methylation status of p16 gene in MM and U266 cell line exposed to As2O3 were detected the nested-methylation specific PCR.
Hai-ying, Fu, Jian-zhen, Shen
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p16 gene alterations in nasopharyngeal carcinoma.

Cancer research, 1995
In order to investigate the p16 gene alterations in nasopharyngeal carcinoma (NPC), we have examined for mutations and deletions of the p16 gene in samples of NPC including 3 cell lines, 3 xenografts, and 20 primary tumors with matched blood DNA as controls.
K W, Lo, D P, Huang, K M, Lau
openaire   +1 more source