Results 81 to 90 of about 47,345 (308)

Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway

Cell Transplantation, 2018
Mesenchymal stem cells (MSCs) constitute an important repair system, but may be impaired by exposure to cardiovascular risk factors. Consequently, adipose tissue-derived MSCs from pigs with the metabolic syndrome (MetS) show decreased vitality. A growing
Y. Meng, A. Eirin, X.-Y. Zhu, H. Tang, L.J. Hickson, A. Lerman, A.J. van Wijnen, L.O. Lerman   +7 more
doaj   +1 more source

Inactivation of p16 gene in leukemia.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2003
To determine the frequency of p16 gene inactivation in leukemia cells, and to evaluate their value in the prediction of their clinical outcome. Bone marrow or peripheral blood samples from 48 patients with leukemia were examined by multiplex polymerase chain reaction (MPCR) to detect p16 gene homozygous deletion, and restriction enzyme PCR to detect ...
C, Wenming, Z, Jiazhi, T, Shuzhen, X, Bai, L, Jingzhong   +4 more
openaire   +1 more source

Expression of genes involved in the regulation of p16 in psoriatic involved skin

, 2006
It has been suggested that the up-regulation of the tumour suppressor p16 gene and induction of senescence protect the phenotype of psoriatic involved skin from malignant transformation.
Björntorp Mark, Elisabeth,, Asp, Julia,, Wennberg, Ann-Marie,, Jonsson, Marianne,, Lindahl, Anders,, Mölne, Lena,   +5 more
core   +1 more source

Inactivation patterns of p16/INK4A in oral squamous cell carcinomas. [PDF]

, 2004
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to evaluate inactivation patterns of p16/INK4A in oral squamous cell carcinoma.
Kim, MJ, Lee, JK, Hong, SD, Hong, Seong-Doo, Kim, Myung-Jin, Hong, SP, Lee, Jeong-Keun, Hong, Sam-Pyo   +7 more
core   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

List of genes under the control of both p16 and E2F1.

, 2013
List of genes under the control of both p16 and E2F1.
Albandary Al-Bakheet (347792), Khalid S. Khabar (347798), Nujoud Al-Yousef (24709), Siti-Faujiah Hendrayani (347794), Maher Al-Saif (347790), Dilek Colak (32197), Namik Kaya (347797), Huda H. Al-Khalaf (24708), Abdelilah Aboussekhra (24710)   +8 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

BMC Cancer, 2009
Background Several genetic alterations have been demonstrated to contribute to the development and progression of melanoma. In this study, we further investigated the impact of key-regulator genes in susceptibility and pathogenesis of such a disease ...
Canzanella Sergio, Stanganelli Ignazio, Pagani Elena, Ascierto Paolo A, Caracò Corrado, Budroni Mario, Cossu Antonio, Muggiano Antonio, Casula Milena, Sini MariaCristina, Palomba Grazia, Palmieri Giuseppe   +11 more
doaj   +1 more source

Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis

, 1999
We have performed representational difference analysis (RDA) on DNA from tumor cells and normal fibroblasts isolated from the ascites of a patient with ovarian cancer. Five of six products of the RDA were homozygously deleted from the tumor DNA.
Perry, P, Morrison, H, Gabra, H, Taylor, K J, Watson, J E, Porteous, D J, Rabiasz, G J, Smyth, J F   +7 more
core  

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source