Results 1 to 10 of about 373,061 (142)

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination [PDF]

EMBO Molecular Medicine, 2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that ...
Maria Francesca Baietti, Michal Simicek, Layka Abbasi Asbagh, Enrico Radaelli, Sam Lievens, Jonathan Crowther, Mikhail Steklov, Vasily N Aushev, David Martínez García, Jan Tavernier, Anna A Sablina   +10 more
doaj   +2 more sources

K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer [PDF]

Vojnosanitetski Pregled, 2009
Beckground/Aim. K-ras oncogene is mutated in about 20% of lung cancer. The purpose of this study was to investigate the predictive significance for therapeutic response of K-ras mutations in advanced non-small cell lung cancer (NSCLC) patients.
Cvetković Gordana, Plavec Goran, Tomić Ilija, Ilić Vesna, Magić Zvonko, Tatomirović Željka, Novković Dobrivoje, Milić Rade, Karličić Vukojica   +8 more
doaj   +1 more source

Identification, classification and expression analysis of the Ras superfamily genes in the Pacific white shrimp, Litopenaeus vannamei

Frontiers in Marine Science, 2023
The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial
Shuqing Si, Shuqing Si, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Jianbo Yuan, Jianbo Yuan, Jianbo Yuan, Xiaoxi Zhang, Xiaoxi Zhang, Xiaoxi Zhang, Yang Yu, Yang Yu, Yang Yu, Song Yang, Fuhua Li, Fuhua Li, Fuhua Li   +18 more
doaj   +1 more source

Mutations of RAS genes identified in acute myeloid leukemia affect glycerophospholipid metabolism pathway

Frontiers in Oncology, 2023
BackgroundAcute myeloid leukemia (AML) is a malignant disease originating from myeloid hematopoietic stem cells. Recent studies have shown that certain gene mutations promote tumor cell survival and affect the prognosis of patients by affecting metabolic
Tianqi Liang, Yanxiang Kong, Hongman Xue, Wenqing Wang, Chunmou Li, Chun Chen   +5 more
doaj   +1 more source

Genome-Wide Identification of Immune-Related Alternative Splicing and Splicing Regulators Involved in Abdominal Aortic Aneurysm

Frontiers in Genetics, 2022
The molecular mechanism of AAA formation is still poorly understood and has not been fully elucidated. The study was designed to identify the immune-related genes, immune-RAS in AAA using bioinformatics methods.
Shiyong Wu, Shibiao Liu, Ningheng Chen, Chuang Zhang, Hairong Zhang, Xueli Guo   +5 more
doaj   +1 more source

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. [PDF]

PLoS ONE, 2012
Certain oncolytic viruses exploit activated Ras signaling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-
Sherri L Christian, Dong Zu, Maria Licursi, Yumiko Komatsu, Theerawat Pongnopparat, Dianne A Codner, Kensuke Hirasawa   +6 more
doaj   +1 more source

RASopathies and cardiac manifestations

Frontiers in Cardiovascular Medicine, 2023
As binary switches, RAS proteins switch to an ON/OFF state during signaling and are on a leash under normal conditions. However, in RAS-related diseases such as cancer and RASopathies, mutations in the genes that regulate RAS signaling or the RAS itself ...
Nazia Hilal, Nazia Hilal, Nazia Hilal, Zi Chen, Zi Chen, Ming Hui Chen, Ming Hui Chen, Sangita Choudhury, Sangita Choudhury, Sangita Choudhury   +9 more
doaj   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source

In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.

PLoS ONE, 2014
It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level T-cell ...
Stephen J Lynch, Jiri Zavadil, Angel Pellicer   +2 more
doaj   +1 more source

The role of ras gene in the development of haemic neoplasia in Mytilus trossulus [PDF]

, 2006
Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown.
Barber, Bos, Ciocan, Corina M. Ciocan, Elston, James D. Moore, Jeanette M. Rotchell, Moore, St-Jean, Van Beneden   +9 more
core   +2 more sources