Results 241 to 250 of about 1,074,277 (302)

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation. [PDF]

J Exp Med
Calderón L, Schäfer M, Rončević M, Rauschmeier R, Jaritz M, Schwickert TA, Sun Q, Pauli A, Zuber J, Busslinger M.   +9 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Resveratrol Mediates Anti-Atherogenic Actions In Vitro and in LDL Receptor-Deficient Mice Fed a High-Fat Diet via Antioxidant, Anti-Inflammatory and Plaque-Stabilising Activities. [PDF]

Antioxidants (Basel)
Alahmadi A, Alotibi R, Chan YH, Taha S, Rifqi D, Alshehri N, Alalawi S, Alradi F, Gibbs A, Hughes TR, Ramji DP.   +10 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The <i>Pseudomonas aeruginosa</i> Cpx system provides a cyclic-di-GMP independent link between cell envelope stress and surface sensing. [PDF]

mBio
O'Malley MR, Dearing HN, Zheng X, Kretschmer AN, Cho TH-S, Raivio TL, Parsek MR.   +6 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

RegNetwork 2025: an integrative data repository for gene regulatory networks in human and mouse. [PDF]

Nucleic Acids Res
Li B, Wang C, Wang Y, Li P, Liu ZP.
europepmc   +1 more source

Gene Regulation

Molecular Therapy, 2000
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The Bacillus subtilis putative LysR-type transcriptional regulator YybE and its connection to chromosome replication and segregation. [PDF]

Access Microbiol
Koh A.
europepmc   +1 more source