Results 131 to 140 of about 2,134,276 (240)

Cutaneous Leiomyosarcoma of the Skin: An Updated Review of Epidemiology, Pathogenesis, and Management

International Journal of Dermatology, Volume 65, Issue 11, Page 2232-2238, November 2026.
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi, Natalie Garcia, Malak Husseinali, Nabeeha Engineer, Ikue Shimizu   +4 more
wiley   +1 more source

Expression and amplification of therapeutic target genes in retinoblastoma [PDF]

, 2018
Purpose: We set out to evaluate alterations of the therapeutic target genes KIT (CD 117), EGFR, and HER-2 in human retinoblastoma. Methods: Ninety-five formalin-fixed, paraffin-embedded retinoblastomas were brought into a tissue microarray (TMA) format ...
Schraml, Peter, Glatz, Katharina, Sauter, Guido, Meyer, Peter, Bösch, Doris, Pache, Mona, Mirlacher, Martina, Flammer, Josef, Simon, Ronald   +8 more
core  

Presentation_1_Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors.pdf

, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Sailaja V. Elchuri (265426), Lakshmi Dhevi Nagarajha Selvan (1321761), Ranjith Kumar (6591521), Vikas Khetan (674092), Debashis Sahoo (47918), Swetha Rajasekaran (6591518), Madhoolika Bisht (6591524), Karthikeyan Sivaraman (503556), Moray J. Campbell (14391), Kathleen Dotts (3767590), Wayne O. Miles (6591530), Pukhraj Rishi (674094), Subrmanian Krishnakumar (6591527)   +12 more
core   +1 more source

Structure and expression of the chicken retinoblastoma gene.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1994
The molecular cloning and initial characterization of the complementary DNA encoding the chicken homologue of the human retinoblastoma susceptibility gene product Rb are described. Chicken Rb (chRb) was found to be highly homologous to human, mouse, and Xenopus Rb in primary amino acid sequence, underlining its conserved function in cell cycle control ...
Boehmelt, Guido, Ulrich, Eugen, Kurzbauer, Robert, Mellitzer, Georg, Bird, Adrian, Zenker, Martin   +5 more
openaire   +2 more sources

Risk definition and management strategies in retinoblastoma: current perspectives

, 2015
Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in ...
Khodabande A, Ghassemi F
core  

The genomic landscape of retinoblastoma: a review

, 2013
Retinoblastoma is a paediatric ocular tumour that continues to reveal much about the genetic basis of cancer development. Study of genomic aberrations in retinoblastoma tumours has exposed important mechanisms of cancer development and identified ...
Brenda L Gallie, Thériault, Brigitte L., Gallie, Brenda L., Brigitte L Thériault, Dimaras, Helen, Helen Dimaras, Corson, Timothy W., Timothy W Corson   +7 more
core   +1 more source

Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells

International Journal of Biological Sciences, 2010
Bone morphogenetic proteins (BMPs) - expressed in the developing retina - are known to be involved in the regulation of cell proliferation and apoptosis in several tumor entities.
Maike Haubold, Andreas Weise, Harald Stephan, Nicole Dünker
doaj  

Targeting ALDOA to modulate tumorigenesis and energy metabolism in retinoblastoma

iScience
Summary: This study aims to elucidate the pivotal role of aldolase A (ALDOA) in retinoblastoma (RB) and evaluate the potential of the ALDOA inhibitor itaconate in impeding RB progression.
Yinghao Wang, Junjie Tang, Yaoming Liu, Zhihui Zhang, Hongwei Zhang, Yujun Ma, Xinyue Wang, Siming Ai, Yuxiang Mao, Ping Zhang, Shuxia Chen, Jinmiao Li, Yang Gao, Chao Cheng, Cheng Li, Shicai Su, Rong Lu   +16 more
doaj   +1 more source

PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair

Scientific Reports
Retinoblastoma (RB) is the most common malignant eye tumor in children. Cytotoxic drugs like melphalam often cause significant side effects and acquired resistance in RB treatment.
Longge Sun, Zhaokang Xu, Xin Zhang, Xing Du, Guanghui Li, Yuanyuan Guo   +5 more
doaj   +1 more source

Identification of genes involved in progression of retinoblastoma [PDF]

, 2005
Many retinoblastomas (RBs) show genomic alterations in addition to mutational loss of both normal RB1 alleles. The most frequent of these changes are gains on chromosomes 1q and 6p and losses on 16q.
Gratias, Sandrine
core