Results 121 to 130 of about 2,134,276 (240)

RETRACTED: Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators.

PLoS Genetics, 2018
Retinoblastoma (pRb) is a multifunctional regulator, which was likely present in the last common ancestor of all eukaryotes. The Arabidopsis pRb homolog RETINOBLASTOMA RELATED 1 (RBR1), similar to its animal counterparts, controls not only cell ...
Daniel Bouyer, Maren Heese, Poyu Chen, Hirofumi Harashima, Francois Roudier, Christian Grüttner, Arp Schnittger   +6 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Productive or Transforming? How Epithelial Compartmentalization of HPV DNA and E6/E7 Transcripts Shapes Cervical Screening Assay Performance

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The human papillomavirus (HPV) life cycle is linked to epithelial cell differentiation, with viral genome amplification, E6/E7 transcription, and virion assembly spatially compartmentalized within the cervical epithelium. This organization is disrupted in transforming lesions.
Konstanze Schichl, John Doorbar
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

MARCADORES GENÉTICOS DO RETINOBLASTOMA: O GENE SUPRESSOR DE TUMOR RB E OUTROS POSSÍVEIS ALVOS TERAPÊUTICOS

, 2019
O retinoblastoma é o tumor ocular maligno mais comum em crianças, manifestando-se geralmente, entre o nascimento e os cinco anos de idade. Sabe-se que têm maior incidência em países em desenvolvimento do que em países desenvolvidos.
Soares, Kristy
core  

Role of Sirtuins in the Hallmarks of Skin Aging

Aging Cell, Volume 25, Issue 11, November 2026.
In the skin, sirtuins support the integrity of the epidermis and dermis and protect the skin from environmental insults by maintaining cellular homeostasis. Sirtuins decline with chronological age, contributing to the biological hallmarks of aging, with increasing evidence emerging of their specific roles in skin aging.
Rishabh Kala, Antonella Rella, Whitby Eagle, Earl Goyarts, Jian Cao, Binwei Deng, Kelly Dong, Chloe Schmit, Matthew Cappock, Krystle Corallo, Jacqueline Trivero   +10 more
wiley   +1 more source

Follow-up of Cystic Pineal Glands in Retinoblastoma Patients Does Not Increase Detection of Pineal Trilateral Retinoblastoma.

To evaluate the effectiveness of baseline screening and follow-up with magnetic resonance imaging (MRI) for detecting trilateral retinoblastoma (TRb) and assessing the risk of TRb development. Prospective multicenter cohort study.
Casseri, T., Koob, M., Pieperjohanns, D., de Haan, J., Gironi, F., de Graaf, P., Maeder, P., Sirin, S., de Bloeme, C.M., Galluzzi, P., Moll, A.C., Ketteler, P., Jansen, R.W., Pasca, A., de Jong, M.C., Göricke, S., Pieperjohanns, Debbie, Koob, Meriam, Pasca, Alessandra, Gironi, Federica, Jansen, Robin W; https://orcid.org/, Moll, Annette C; https://orcid.org/, de Graaf, Pim; https://orcid.org/, Ketteler, Petra; https://orcid.org/, Casseri, Tommaso, Sirin, Selma; https://orcid.org/, de Jong, Marcus C; https://orcid.org/, Galluzzi, Paolo; https://orcid.org/, European Retinoblastoma Imaging Collaboration, Maeder, Philippe; https://orcid.org/, de Bloeme, Christiaan M; https://orcid.org/, de Haan, Joeka; https://orcid.org/, Göricke, Sophia   +32 more
core   +1 more source

The potential of 3T high-resolution magnetic resonance imaging for diagnosis, staging, and follow-up of retinoblastoma.

, 2015
We demonstrate the value of high-resolution magnetic resonance imaging (MRI) in diagnosing, staging, and follow-up of retinoblastoma during eye-saving treatment.
Beck-Popovic, M., Munier, F.L., de Graaf, P., Maeder, P., Castelijns, J.A., Galluzzi, P., Moll, A.C., Binaghi, S., Moulin, A.P., de Jong, M.C., Brisse, H.J., Popovic MB, Castelijns JA, Moll AC, Binaghi S, de Graaf P, Moulin AP, Munier FL, Brisse HJ, Maeder P, de Jong MC, Göricke SL, Galluzzi P, Göricke, S.L.   +23 more
core   +1 more source

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 994-999, November 2026.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

Managing and treating intraocular retinoblastoma [PDF]

, 2018
In order to improve the survival rates of children with retinoblastoma, a collaborative and multidisciplinary approach is essential, as is a listening ear for parents who may struggle with the difficult decisions facing ...
Vikas Khetan, Mukesh Jain, Ashwin Reddy
core