Results 111 to 120 of about 2,134,276 (240)

The molecular progression from retina through retinoma to retinoblastoma and the role of the p75(NTR) neurotrophin receptor [PDF]

, 2007
Retinoblastoma, a childhood cancer of the retina, is initiated by the loss of RB1; genomic gains of oncogenes (KIF14, DEK, E2F3, MYCN) and loss of tumor suppressor genes (CDH11) are essential for malignant progression.
Dimaras, Helen
core   +1 more source

Retinoma: An overview

Pediatric Investigation
Retinoma, also referred to as retinocytoma, is a benign manifestation of biallelic retinoblastoma gene (RB1) inactivation. Genetic or epigenetic loss of retinoblastoma protein in maturing cone precursors induces genomic instability which leads to ...
Panagiotis N. Toumasis, Ashwin Mallipatna, Timothy W. Corson, Helen Dimaras   +3 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

Molecular & Cellular Oncology, 2018
The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing
Kotaro Fujimaki, Guang Yao
doaj   +1 more source

Setting up an Intra‐Arterial Chemotherapy Center in a Low‐Resource Country in Sub‐Saharan Africa

Public Health Challenges, Volume 5, Issue 4, December 2026.
Ghana established West Africa's first intra‐arterial chemotherapy service for retinoblastoma through a public–private partnership between Korle Bu Teaching Hospital and Euracare, delivering 32 treatment sessions for 10 children. Strategic partnerships, training, and phased implementation can make this vision‐ and life‐saving therapy achievable in low ...
Vera Adobea Essuman, Benjamin Dabo Sarkodie, Dziffa‐Bella Imelda‐Odille Ofori‐Adjei, Vera Mawusime Beyuo, Andrea Nimako, Abigail Nyarko Bosompem, Lauretta Pinamang Owusu‐Asare, Yaw Akye Essuman, Benjamin Abaidoo, Fred Kwabena Osei, Dong Jatoe, Lorna Awo Renner, Naa Naamuah Tagoe, Kwesi Nyan Amissah‐Arthur   +13 more
wiley   +1 more source

Copy‐Number Alterations in Central Nervous System Tumours: Diagnostic and Prognostic Implications

Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.
This review summarises recurrent copy‐number alterations across the spectrum of CNS tumours, classifies them into diagnostic, prognostic and supportive categories, and highlights how characteristic CNA combinations support tumour classification, grading and risk stratification in neuropathological diagnostics.
Christian Thomas
wiley   +1 more source

Evasion of targeted cancer therapy through stem-cell-like reprogramming

Molecular & Cellular Oncology, 2017
Prostate cancer variants expressing alternative lineage markers appear at relapse from antiandrogen therapy. We show that loss of the retinoblastoma (RB1) and tumor protein 53 (TP53) genes drives expression of stem cell reprogramming factors, lineage ...
Kristine M. Wadosky, Leigh Ellis, David W. Goodrich   +2 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, Volume 600, Issue 21, Page 3221-3240, November 2026.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, Volume 20, Issue 11, Page 2699-2717, November 2026.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source