Results 91 to 100 of about 2,134,276 (240)

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Molecular Biology of Retinoblastoma

, 2015
The molecular biology of retinoblastoma has led to a revolution in our understanding of cancer biology. This chapter reviews the discovery and subsequent elucidation of RB1, the first tumor suppressor gene, and its protein product, Rb.
Walter, Scott D, Harbour, J. William, Scott D. Walter, J. William Harbour   +3 more
core   +2 more sources

A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions

Cancer Cell International, 2010
Background The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a ...
Demone Jordan, Francis Sarah M, Henley Shauna A, Ainsworth Peter, Dick Frederick A   +4 more
doaj   +1 more source

CDK4/6 Inhibitors and Curcumin Synergistically Suppress HER2− Breast Cancer via Lethal ROS and Inhibition of Metastasis

Cancer Science, EarlyView.
Schematic illustrating that CDK4/6 inhibitors combined with curcumin induce lethal ROS accumulation by disrupting redox balance, downregulating GPX4, and depleting glutathione, leading to DNA damage and lipid peroxidation. This oxidative stress triggers tumor cell death and suppresses EMT‐driven migration.
Chenyu Wang, Yiqin Zou, Chunyu Chang, Siyue Liu, Xiankun Ke, Liang Hu, Di Wang, Yukang Lu, Shiwen Luo, Sijian Huang, Yilan Hu, Wenqi Yu, Aiping Deng, Ming Yue, Jue Jiang   +14 more
wiley   +1 more source

Identification of miR-20a as A Potential Discerning Biomarker for Non-Invasive versus Invasive Retinoblastoma [PDF]

Cell Journal
Objective: Intraocular retinoblastoma (RB) is common in kids. Although the cause of this disease is a mutation in theRB1 gene, the formed cancerous mass in different patients is seen in non-invasive states, limited to the ocular cavityor in invasive ...
Ahmad Bereimipour, Saeed Karimi, Mohammad Faranoush, Amir Abbas Hedayati Asl, Monireh sadat Miri, Leila Satarian, Sara Taleahmad   +6 more
doaj   +1 more source

Cellular Proliferation and Reprogramming in Pre‐Metastatic Niches: Mechanisms and Therapeutic Vulnerabilities

Cell Proliferation, EarlyView.
This review systematically elucidates how primary tumours remotely drive multicellular reprogramming to construct the pre‐metastatic niche and dictate disseminated tumour cell fate. By mapping this dynamic ecosystem, we identify actionable therapeutic vulnerabilities, advocating a paradigm shift from traditional cytotoxicity toward microenvironment ...
Shengqian Wang, Chenghu Song, Pengfei Li, Junjie Feng, Xiaoxuan Shi, Qiwen Lu, Bohan Duan, Xinyan Zhang, Siqi Li, Yang Luo, Xiaohui Fan, Ziyun Li, Yang Zhang, Renjun Gu, Wenjun Mao   +14 more
wiley   +1 more source

Expression of the neurodevelopmental disease susceptibility genes CADM1 and CADM2 in the early human fetal forebrain

Journal of Anatomy, EarlyView.
CADM1 and CADM2 are related cell‐adhesion molecules that show differential patterns of expression in early human fetal forebrain. Although often co‐expressed in neurons, CADM2 protein exclusively and selectively localises to axons, whereas CADM1 is predominantly expressed in the nucleus, posing questions as to what their developmental roles might be ...
Natalie Wucherer, Maznah Alhesain, Amn Ashhad, Marc Woodbury‐Smith, Gavin J. Clowry   +4 more
wiley   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source

How we manage patients with retinoblastoma [PDF]

, 2018
When a child with retinoblastoma reports to our centre, a message is immediately passed on to a physician who treats ...
Vikas Khetan
core  

Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases

Oral Diseases, EarlyView.
ABSTRACT Objective Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment‐related, and survival features of OSJ in Latin America. Methods This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela,
Victor Zanetti Drumond, José Alcides Almeida de Arruda, Mariana Villaroel‐Dorrego, Leonardo Amaral Dos Reis, Gerhilde Callou Sampaio, Lauren Frenzel Schuch, Carolina Louzada Menna‐Barreto, Manoela Domingues Martins, Paula Celeghini Goulart, Guilherme Gomes Souza, Fabrício Tinôco Alvim de Souza, Warley Oliveira Silva, Karina Cordero‐Torres, Rolando Morales‐Espinosa, René Panico, Gerardo Gilligan, Federico Garola, Carlos Marcelo Cerullo, Nicolás Leonardi, Javier Giménez, Verónica Flück, Ángeles Castrillo, Laura Leguina, Claudia Patricia Peña‐Vega, Juan Pablo Rodríguez‐Mora, Kallana Mezzomo‐Faccin, Ricardo Luiz Cavalcanti de Albuquerque‐Junior, Rogério Gondak, Mônica Simões Israel, Pollianna Muniz Alves, Amanda Claudino Gomes, Cassiano Francisco Weege Nonaka, Michel Campos Ribeiro, Elismauro Francisco de Mendonça, Victor Hugo Lopes de Oliveira Moreira, Diego Antônio Costa Arantes, Israel Leal Cavalcante, Eveline Turatti, Roberta Barroso Cavalcante, Giovanna Tacchi, Ana Paula Neutzling Gomes, Karen Müller Bubolz, Adriana Etges, María Natalia González Umpiérrez, Natalia Fernanda Tancredi Cueto, Aurita Verónica Beovide‐Cortegoso, Ronell Bologna‐Molina, Saray Aranda‐Romo, Francisco Javier Tejeda‐Nava, Lucas Guimarães Abreu, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita   +51 more
wiley   +1 more source