Results 81 to 90 of about 2,134,276 (240)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Top 10 genes downregulated after increased microRNA-31 and -200a expression in Y79 retinoblastoma cells.

, 2015
Top 10 genes downregulated after increased microRNA-31 and -200a expression in Y79 retinoblastoma cells. Genes were identified as being downregulated on the basis of a statistically significant fold change (p-value < 0.05) in expression level for the ...
Hongmei Jiang (31560), Joshua Martin (796802), Gang Feng (130630), Vanessa Montoya (796798), Hanli Fan (113278), Nikia A. Laurie (796804), Marilyn B. Mets (796801), Paul J. Bryar (796799), Alissa Martin (796803), Joanna L. Weinstein (796800)   +9 more
core   +1 more source

Transcriptome profiling of uterine leiomyosarcomas identifies a leiomyoma-like expression pattern that indicates better survival

BJC Reports
Background Uterine leiomyosarcomas are rare and aggressive cancers with poor survival. Their non-cancerous counterparts, uterine leiomyomas, are common tumors affecting many women during reproductive years.
Sara Khamaiseh, Riitta Koivisto-Korander, Nora Schreiber, Esa Pitkänen, Terhi Ahvenainen, Ralf Bützow, Miika Mehine, Pia Vahteristo   +7 more
doaj   +1 more source

Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use

The Prostate, EarlyView.
ABSTRACT Background Research on prostate cancer and benign prostatic hyperplasia depends on a small number of immortalized human cell lines established between 1977 and 2001, most of them from advanced metastatic disease. The cell lines differ from one another in androgen receptor status, prostate‐specific antigen secretion, p53 status, karyotype and ...
Hamza Abohamra, Keenau Mark Pearce
wiley   +1 more source

RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development

Frontiers in Genetics, 2018
Retinoblastoma is rare tumor of the retina caused by the homozygous loss of the Retinoblastoma 1 tumor suppressor gene (RB1). Loss of the RB1 protein, pRB, results in de-regulated activity of the E2F transcription factors, chromatin changes and ...
Sailaja V. Elchuri, Swetha Rajasekaran, Swetha Rajasekaran, Swetha Rajasekaran, Wayne O. Miles, Wayne O. Miles, Wayne O. Miles   +6 more
doaj   +1 more source

The Retinoblastoma Gene in Myeloid Leukaemias

Hematology, 1996
The balance between self-renewal, differentiation and programmed cell death underlies normal haemopoiesis. Disruption of this balance results in leukaemogenesis which is believed to be a multi-step process, culminating in the clonal selection and expansion of an abnormal haemopoietic progenitor cell.
openaire   +2 more sources

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Global Retinoblastoma Presentation and Analysis by National Income Level.

, 2020
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late.
De Potter, Patrick, Global Retinoblastoma Study Group, Brichard, Bénédicte   +2 more
core   +1 more source

Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition

Brain Pathology, EarlyView.
DNA methylation profiling identifies GPAP as a distinct circumscribed glioma with a characteristic expansive, multicystic radiological appearance, pleomorphic and pseudopapillary histology, a recognizable CNV profile, druggable molecular alterations, and recurrent cancer predisposition syndromes.
Alberto Picca, Valeria Barresi, Aude Trinquet, Luca Bertero, Lucia Nichelli, Guillaume Chotard, Michèle Bernier, Thomas Gareau, Salah Eddine Oussama Kacimi, Jaydutt Bhalshankar, Mathilde Filser, Julien Masliah‐Planchon, Marta Iollo, Henri Malaize, Bertrand Mathon, Luc Bauchet, Kifah Khouri, Besma Barka, Hélène Madry, Sabrina Rossi, Evelina Miele, Giuseppe Kenneth Ricciardi, Catherine Carpentier, Irina Coin, Marc Sanson, Mehdi Touat, Caroline Dehais, Alessia Pellerino, Roberta Rudà, Paola Cassoni, Valérie Rigau, Emmanuelle Uro‐Coste, Karima Mokhtari, Ahmed Idbaih, Patrick R. Benusiglio, Franck Bielle   +35 more
wiley   +1 more source

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]

, 2015
TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R, Harrison, David J, Sheahan, Sharon, Bellamy, Christopher O, Prost, Sandrine   +4 more
core   +1 more source