Results 101 to 110 of about 2,134,276 (240)

Recent Trends in the Management of Retinoblastoma

, 2015
Retinoblastoma is the most common intraocular malignancy of childhood. Significant progress has been made in the past few years in the management of retinoblastoma. Thus, the patients’ survival and ocular salvage rates have shown marked improvement. The
Derda Özer, Ozer, Derda, Samuray Tuncer, Tuncer, Samuray   +3 more
core   +1 more source

Molecular Links Between Heat Stress and DNA Damage Response in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach, Miriam Szurman‐Zubrzycka   +1 more
wiley   +1 more source

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study [PDF]

MYCN-amplified RB1 wild-type (MYCN amp RB1 +/+) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed
Robin W. Jansen, Saugata Sen, Sophia Göricke, Paolo Galluzzi, Pim de Graaf, Matthijs Cysouw, Liesbeth Cardoen, Hervé J. Brisse, Kim E. Nichols, Alison H. Skalet, H. Culver Boldt, Audra K. Miller, Ronald Boellaard, Josephine C. Dorsman, Hans Grossniklaus, Rachel C. Brennan, Mériam Koob, Annette C. Moll, European Retinoblastoma Imaging Collaboration, Charlotte J. Dommering, Aparna Ramasubramanian, Philippe Maeder, Sabien van Elst, Jaime Lyn Jessen, Ogul E. Uner, Marcus C. de Jong, Christiaan M. de Bloeme, Selma Sirin, G. Baker Hubbard, Brennan, Rachel C., de Jong, Marcus C., Dommering, Charlotte J; https://orcid.org/, Moll, Annette C; https://orcid.org/, de Bloeme , Christiaan M., Sen, Saugata; https://orcid.org/, Dorsman, Josephine C., Dorsman, J.C., Hubbard, G Baker; https://orcid.org/, Moll, A.C., Sirin, Selma; https://orcid.org/, Brisse, H.J., Hubbard, G. Baker, Miller, Audra K., Skalet, Alison H, Dommering, C.J., Nichols, Kim E., Cysouw, Matthijs, Skalet, A.H., Ramasubramanian, A., Nichols, Kim E; https://orcid.org/, Moll, Annette C., Ramasubramanian, Aparna, Sen, Saugata, van Elst, S., van Elst, Sabien, de Jong, Marcus C; https://orcid.org/, Cysouw, M., Grossniklaus, H., Jansen, Robin W., Galluzzi, Paolo, Koob, M., Boellaard, Ronald; https://orcid.org/, Boellaard, R., Maeder, Philippe; https://orcid.org/, de Bloeme, Christiaan M; https://orcid.org/, Uner, Ogul E; https://orcid.org/, Sirin, S., de Bloeme, C.M., Jessen, Jaime Lyn, de Jong, M.C., Göricke, S., Uner, Ogul E., Koob, Mériam, Sirin, Selma, Brisse, Hervé J; https://orcid.org/, Uner, O.E., Jansen, Robin W; https://orcid.org/, de Graaf, Pim; https://orcid.org/, Cardoen, Liesbeth, Cardoen, L., Nichols, K.E., Galluzzi, P., Grossniklaus, Hans, Jansen, R.W., Galluzzi, Paolo; https://orcid.org/, Skalet, Alison H., Brennan, Rachel C; https://orcid.org/, Boellaard, Ronald, Boldt, H.C., Miller, A.K., Maeder, Philippe, Brisse, Hervé J., Sen, S., Boldt, H Culver; https://orcid.org/, de Graaf, P., Dorsman, Josephine C, de Graaf, Pim, Jessen, J.L., Cardoen, Liesbeth; https://orcid.org/, Miller, Audra K; https://orcid.org/, Dommering, Charlotte J., van Elst, Sabien; https://orcid.org/, Brennan, R.C., Maeder, P., Boldt, H. Culver, Göricke, Sophia, Hubbard, G.B.   +106 more
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Deletion and inactivation of retinoblastoma susceptibility gene in primary retinoblastoma

Chinese Journal of Cancer Research, 1992
The status and expression of Rb gene was detected and analyzed in 19 surgical retinoblastoma specimens using Rb cDNA 3.8 kb and 0.9 kb fragment as probe and antibodies specific for synthetic Rb peptide or expressive product of Rb gene expression plasmid. DNA from those tumors had the hemizygous deletion in 3 cases, the homozygous internal deletion in 2
Qian Huang, Yingping Deng, Chengran Luo, Qianxun Fang, Jianren Gu, Yuanqing Chen, Huqiu Jiang, Lai Xu, Libin Jia, Dafang Wan, Hongnian Li, Anqing Ma, Shumin Qu   +12 more
openaire   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Enhanced prediction of postlaminar optic nerve invasion in retinoblastoma using high-resolution MRI: integrating qualitative imaging features, optic nerve measurements and tumor radiomics

This study aimed to develop a model for predicting postlaminar optic nerve invasion (PLONI) in retinoblastoma patients using MR imaging. The model was designed to incorporate recent advanced diagnostic techniques, including tumor radiomics, manual and ...
Moor, Maaike, Caan, Matthan W A, Sirin, Selma, Koob, Meriam, Galluzzi, Paolo, de Jong, Marcus C, Maeder, Philippe, Jansen, Robin W, Moll, Annette C, de Graaf, Pim, Cardoen, Liesbeth, Göricke, Sophia, van Elst, Sabien, Cysouw, Matthijs, de Bloeme, Christiaan M, European Retinoblastoma Imaging Collaboration, Sirin, Selma; https://orcid.org/   +16 more
core   +1 more source

Missing evidences in cancer genetics: The retinoblastoma paradigm.

, 2008
BACKGROUND: Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood. The "two hit" theory, formulated by Knudson in 1971 to explain the variegated clinical expression of the disease, led to the discovery of the so called ...
Theodora Hadjistilianou, DE FRANCESCO S., Aldo Di Leonardo, LENTINI, Laura, Sonia De Francesco, DI LEONARDO, Aldo, Laura Lentini, DE FRANCESCO S, MASTRANGELO D., DI LEONARDO A., MASTRANGELO D, Domenico Mastrangelo, HADJISTILIANOU T., LENTINI L.   +13 more
core   +1 more source

Retinoblastoma Tumor Suppressor Gene: An Overview

Journal of Indian Academy of Oral Medicine and Radiology, 2012
A genetic basis for the development of cancer has been hypothesized for nearly a century and has been supported by familial, epidemiological and cytogenetic studies. Current view is that carcinogenesis is a multistep process involving activation of oncogenes or inactivation of tumor suppressor genes.
Sunila Thomas, Anita Balan
openaire   +2 more sources

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

International Journal of Cancer, Volume 159, Issue 12, Page 3029-3037, 15 December 2026.
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Marianne Gardar Stærk, Birgitte Grønkær Toft, Christina Stilling, Johanna Elversang, Sanne Kjær‐Frifeldt, Sonja Höhle Hjulskov, Sanja Stifter‐Vretenar, Marie Aarslev Schou, Mikael Aagaard, Peter Meidahl Petersen, Jakob Kristian Jakobsen, Christian Munk, Susanne Krüger Kjær   +12 more
wiley   +1 more source

Systems‐level phosphoproteomics reveals calcium/calmodulin‐dependent protein kinase kinase 2‐driven kinase signaling underlying malignant phenotypes in gastric cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
CAMKK2 inhibition induces extensive phosphoproteomic remodeling associated with cell cycle regulation, RNA processing, and kinase signaling networks in gastric cancer. Integrated systems‐level analyses identified dysregulated CDK, SRPK, MAPK, and AKT signaling pathways underlying malignant phenotypes and highlighted CAMKK2 as a potential therapeutic ...
Mohd. Altaf Najar, T. S. Keshava Prasad, Prashant Kumar Modi   +2 more
wiley   +1 more source