Results 71 to 80 of about 2,134,276 (240)
Familial Cancers Associated With Cancers of the Breast, Prostate, Colorectum, and Lung in Sweden
International Journal of Cancer, EarlyView.ABSTRACT Available epidemiological evidence shows that many cancers share familial risks, and this is increasingly confirmed by data on shared pathogenic germline gene variants between cancers. We decided to harness the world's largest resource on familial cancer to assess discordant familial risks for female breast (BC), prostate (PC), colorectal (CRC)
Frantisek Zitricky +5 more
wiley +1 more source
Epidemiological and genetic considerations in retinoblastoma [PDF]
, 2018 Retinoblastoma is usually initiated by a random mutation of a gene in a retinal cell. It is important to try and recognise if the child has germline retinoblastoma, as this may affect both eyes of the child.
Sandeep S Sagoo +5 more
core
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report
Frontiers in Oncology, 2020 Malignant ovarian germ cell tumors (MOGCTs) are neoplasms of the ovary, of which, due to their rarity and heterogeneity, few is reported about genetic background and development. Here, we report a 18-years old patient diagnosed with an ovarian mixed germ
Elisa Gelli +14 more
doaj +1 more source
A physical map around the retinoblastoma gene
Genomics, 1990 The gene predisposing to retinoblastoma, RB1, has been mapped to 13q14 and a cDNA clone has been isolated. Alterations of this chromosomal region are found not only in retinoblastoma, but in other tumor types including bone and soft tissue sarcomas, gastric tumors, small cell lung cancer, hematologic malignancies, rhabdomyosarcoma, and breast cancer ...
G M, Ford +3 more
openaire +2 more sources
iNew Medicine, EarlyView.ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu +5 more
wiley +1 more source
Data in Brief, 2016 Retinoblastoma (Rb) is a pediatric intraocular malignancy and probably the most robust clinical model on which genetic predisposition to develop cancer has been demonstrated.
A.J. García-Chequer +19 more
doaj +1 more source
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Detecting retinoblastoma [PDF]
, 2018 It is important to learn the early signs of retinoblastoma.
Manoj V Parulekar
core
The retinoblastoma paradigm revisited
, 2008 BACKGROUND: Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood. The "two hit" theory, formulated by Knudson in 1971 to explain the variegated clinical expression of the disease, led to the discovery of the so called
DE FRANCESCO S. +4 more
core +2 more sources
Consideraciones clínicas, diagnósticas y de tratamiento en retinoblastoma
MedUNAB, 2011 El retinoblastoma es el tumor intraocular primario más frecuente en la infancia. Su detección temprana y el inicio del tratamiento adecuado permiten mejorar dramáticamente la sobrevida en estos niños. En este artículo se hace una revisión general de
Ronald Andrés Serrano Uribe +3 more
doaj