Results 191 to 200 of about 252,546 (355)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Embryonic temperature and the genes regulating myogenesis in teleosts

, 2008
In this study, full coding sequences of Atlantic salmon (Salmo salar L.) muscle genes were cloned, including myogenic regulatory factors (MRFs) (myod1c, myog, mrf4, myf5), inhibitors of Myostatin (fst, decorin), markers of myogenic progenitor cell (MPC ...
Macqueen, Daniel J.
core  

Differential regulation of immunoglobulin class switch recombination by the tumor suppressor p53. [PDF]

Sci Rep
Hanefioui K, Dauba A, Payrault C, Guessous F, Khamlichi AA.   +4 more
europepmc   +1 more source

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

EMBO Journal, 1986
J. Stavnezer-Nordgren, S. Sirlin
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

CFP1 promotes B cell class switch recombination through the regulation of S region germline transcription and proliferation. [PDF]

iScience
Gong S, Zhao Y, Yang Y, Lu Y, Bai J, Liu M, Chen Y, Zhao B, Zhou R, Chen C, Bai W, Dong J.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effects of Lacticaseibacillus rhamnosus L156.4 and Lactococcus lactis NCDO 2118 strains on reducing alcohol intake and preference in an animal model of high alcohol consumption and preference. [PDF]

Sci Rep
Amormino MS, Moreira-Júnior RE, Vasconcelos RA, Dos Santos IN, de Moura Gonçalves ABR, Mendes MV, de Lima Santos J, Barroso FAL, de Carvalho Azevedo VA, Maioli TU, Faria AMC, Ferreira E, Brunialti-Godard AL.   +12 more
europepmc   +1 more source

A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells upon Neural Induction

Cell Cycle, 2004
P. Perry, S. Sauer, N. Billon, W. Richardson, Mikhail Spivakov, G. Warnes, F. J. Livesey, M. Merkenschlager, A. Fisher, V. Azuara   +9 more
semanticscholar   +1 more source