Results 221 to 230 of about 252,546 (355)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Flicking the switch for B-cell development. [PDF]

Genes Dev
Ng AP, Nutt SL.
europepmc   +1 more source

On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.

Nucleic Acids Research, 1982
R. Lang, L. Stanton, K. Marcu
semanticscholar   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Age<b>,</b> C-reactive protein, and hospital stay Are associated with switching from azithromycin to doxycycline in pediatric macrolide-resistant <i>Mycoplasma pneumoniae</i> pneumonia. [PDF]

Front Pediatr
Zhang M, Liu Q, Wei H, Wang A, Wang J, Li H, Jing X.   +6 more
europepmc   +1 more source

Molecular switches for regulating therapeutic genes [PDF]

Gene Therapy, 1999
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A MYC family switch: L-MYC drives and maintains neuroendocrine lineage programs in prostate cancer. [PDF]

Neoplasia
Sivalingam J, Ballagh K, Cho KH, Shi Y, Li L, Barron P, Lan MS, Franco OE, Yu X.   +8 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Genetic Engineering of Lysogenic-Lytic Switch Genes Improves <i>Burkholderia</i> Phage Killing Efficacy. [PDF]

Int J Mol Sci
Khrongsee P, Doore SM, Somprasong N, Schweizer HP, Xiao YP, Subramaniam K, Mergia A, Tuanyok A.   +7 more
europepmc   +1 more source