Results 291 to 300 of about 252,546 (355)

Associate toxin-antitoxin with CRISPR-Cas to harness (ATTACH) engineered microbes. [PDF]

open access: yesNucleic Acids Res
Zhao H   +14 more
europepmc   +1 more source

Fitness effects of antimicrobial resistance genes in changing environments

open access: yes
Escudero JA   +11 more
europepmc   +1 more source

A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

open access: yesScience, 2013
Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified,
G. Andrey   +8 more
semanticscholar   +2 more sources
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Recombinational Switch for Gene Expression

Science, 1977
Flagellar antigens are specified by two genes, H1 and H2. The expression of these genes is regulated such that only one gene activity, or phase, is expressed at a given time. Molecular cloning techniques were used to isolate the segments of Salmonella DNA which contain these genetic loci.
J, Zieg   +3 more
openaire   +2 more sources

An edible switch for gene therapy

Nature Biotechnology, 2016
The expression of therapeutic transgenes in mice is made responsive to the amino acid content of the diet.
Xavier M, Anguela, Katherine A, High
openaire   +2 more sources

Novel Gene Switches

2007
Controlling gene activity in space and time represents a cornerstone technology in gene and cell therapeutic applications, bioengineering, drug discovery as well as fundamental and applied research. This chapter provides a comprehensive overview of the different approaches for regulating gene activity and product protein formation at different ...
Weber W, Fussenegger M
openaire   +3 more sources

Chimeric receptors as gene switches

Current Opinion in Biotechnology, 1997
There is a recognized need for eukaryotic molecular gene switches that are tightly regulated by the administration of small molecule drugs. The modular nature of intracellular receptor proteins has allowed the recent development of chimeric receptors that fulfill this need.
V E, Allgood, E M, Eastman
openaire   +2 more sources

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