Results 301 to 310 of about 252,546 (355)

Globin gene switching in primates

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2002
Evolutionary approaches to the identification of DNA sequences required for transcription of the genes of the beta-globin cluster are reviewed. Sequence alignments of non-coding regions from widely divergent species revealed many conserved motifs (phylogenetic footprints) that were putative transcription factor binding sites and candidate binding ...
Robert M, Johnson, Deborah, Gumucio, Morris, Goodman   +2 more
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Switching genes in Schizosaccharomyces pombe

Current Genetics, 1985
In homothallic (h 90) Schizosaccharomyces pombe strains mutants occur which exhibit reduced frequencies of mating-type switching. The colonies of such mutants show a mottled iodine reaction. The underlying mutations map either in a switching signal at matl or in switching (swi) genes which are not linked to the mating-type region.
H, Gutz, H, Schmidt
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An On/Off Switch for Genes

Scientific American, 2015
The article reports that researchers are developing molecular switches that can inactivate transplanted genes and present another step in making safer gene therapies and better treatments for cancer. Topics discussed include difficulty faced by researchers in early experiments in gene therapy regarding controlling activity of newly inserted genes ...
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Switching Gene Regulatory Networks

2015
A fundamental question in biology is how cells change into specific cell types with unique roles throughout development. This process can be viewed as a program prescribing the system dynamics, governed by a network of genetic interactions. Recent experimental evidence suggests that these networks are not fixed but rather change their topology as cells
Yoli Shavit, Boyan Yordanov, Sara-Jane Dunn, Christoph M. Wintersteiger, Youssef Hamadi, Hillel Kugler   +5 more
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Gene Switching and Essentiality Testing

2009
The identification of essential genes is of major importance to mycobacterial research, and a number of essential genes have been identified in mycobacteria, however confirming essentiality is not straightforward, as deletion of essential genes results in a lethal phenotype.
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Leukodystrophy and Gene Therapy with a Dimmer Switch

New England Journal of Medicine, 2011
Globoid-cell leukodystrophy is a neurodegenerative disease characterized by the loss of central and peripheral myelin. It is treated by autologous transplantation of hematopoietic stem cells. A recent study provides proof of concept of a new approach to gene therapy.
Paul J, Orchard, John E, Wagner
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Cluster Switches in Gene Expression Data

2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018
Following the sequencing of the human genome, the next step is to understand the function of all genes in health and disease. However, experimental study of the functions of all genes in all diseases is impossible and unnecessary, as not all genes are functional in all conditions.
Maayan Hassidim, Guy Shani, Tal Shay
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RENIN GENE EXPRESSION: THE SWITCH AND THE FINGERS

Clinical and Experimental Pharmacology and Physiology, 2001
SUMMARY1. Now that many of the factors and control elements that regulate renin transcription have been identified, the scene is set to address the question of the mode of control.2. Based on current gene control theories, either renin gene transcription in each cell undergoes gradual responses over a continuous range or transcription is switched ...
B J, Morris, D J, Adams, L, van der Weyden   +2 more
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The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Science, 2010
A. Levine, Anna M. Puzio-Kuter
semanticscholar   +1 more source

GENE-SWitCH GENE-SWitCH Data Management Plan

2019
Report on the data management plan for GENE-SWitCH in accordance with the latest FAANG data standards, SOPs and FAANG Data Sharing Principles.
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