Results 41 to 50 of about 480,900 (296)

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Advanced Science, 2022
Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You   +9 more
doaj   +1 more source

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources

The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2

Biomolecules
The transcription factor E2F1 is the principal target of the tumor suppressor pRB. E2F1 promotes cell proliferation by activating growth-promoting genes upon growth stimulation.
Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani   +13 more
doaj   +1 more source

The Effect of 5-Aza-2′-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apop

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Background: Aberrant methylation and histone deacetylation of tumor suppressor genes (TSGs) are the most epigenetic alterations involving in tumorigenesis.
Masumeh Sanaei, Fraidoon Kavoosi, Zahra Esmi   +2 more
doaj   +1 more source

Breast Cancer Stem Cells and Tumor Suppressor Genes

Journal of the Formosan Medical Association, 2008
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear.
Wendy W. Hwang-Verslues, King-Jen Chang, Eva Y.-H.P. Lee, Wen-Hwa Lee   +3 more
doaj   +1 more source

The role of miR-24 as a race related genetic factor in prostate cancer. [PDF]

, 2017
The incidence of prostate cancer (PCa) among African-Americans (AfA) is significantly higher than Caucasian-Americans (CaA) but the genetic basis for this disparity is not known.
Dahiya, Rajvir, Dasgupta, Pritha, Deng, Guoren, Hashimoto, Yutaka, Kato, Taku, Kulkarni, Priyanka, Kumar, Deepak, Majid, Shahana, Mitsui, Yozo, Saini, Sharanjot, Shahryari, Varahram, Shiina, Marisa, Sumida, Mitsuho, Tabatabai, Laura, Tanaka, Yuichiro, Yamamura, Soichiro   +15 more
core   +1 more source

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer.
Li Ti-yuan, Zhou Shu-yan, Sun Ye-hong, Chen Fu-qiang, Zhang Yi, Chen Rui   +5 more
doaj   +1 more source

Identifying genes with tri-modal association with survival and tumor grade in cancer patients

BMC Bioinformatics, 2019
Background Previous cancer genomics studies focused on searching for novel oncogenes and tumor suppressor genes whose abundance is positively or negatively correlated with end-point observation, such as survival or tumor grade.
Minzhe Zhang, Tao Wang, Rosa Sirianni, Philip W. Shaul, Yang Xie   +4 more
doaj   +1 more source

CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin. [PDF]

PLoS ONE, 2014
The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma.
Mohammad Fallahi, Antonio L Amelio, John L Cleveland, Robert J Rounbehler   +3 more
doaj   +1 more source