A novel unsupervised method to identify genes important in the anti-viral response: application to interferon/ribavirin in hepatitis C patients. [PDF]
PLoS ONE, 2007 Treating hepatitis C with interferon/ribavirin results in a varied response in terms of decrease in viral titer and ultimate outcome. Marked responders have a sharp decline in viral titer within a few days of treatment initiation, whereas in other ...
Leonid I Brodsky +5 more
doaj +14 more sources
Non-viral approaches to gene therapy [PDF]
Current Opinion in Biotechnology, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Behr +44 more
core +5 more sources
Importance of Target Gene Locus on the Stability of Recombinant Viruses in the Baculovirus Expression System [PDF]
VirusesIn the baculovirus expression system, recombinant viruses generated via bacmids often exhibit reduced expression and genetic stability of target genes during serial passages.
Jong Ho Lee +3 more
doaj +2 more sources
Viral gene drive in herpesviruses [PDF]
Nature Communications, 2019 AbstractHerpesviruses are ubiquitous pathogens in need of novel therapeutic solutions. Current engineered gene drive strategies rely on sexual reproduction, and are thought to be restricted to sexual organisms. Here, we report on the design of a novel gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in ...
Walter, Marius, Verdin, Eric
openaire +5 more sources
Pseudorabies virus infected porcine epithelial cell line generates a diverse set of host microRNAs and a special cluster of viral microRNAs. [PDF]
PLoS ONE, 2012 Pseudorabies virus (PRV) belongs to Alphaherpesvirinae subfamily that causes huge economic loss in pig industry worldwide. It has been recently demonstrated that many herpesviruses encode microRNAs (miRNAs), which play crucial roles in viral life cycle ...
Yi-Quan Wu +6 more
doaj +1 more source
Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases. [PDF]
PLoS ONE, 2015 Viral agents are of interest as possible autoimmune triggers due to prior reported associations and widely studied molecular mechanisms of antiviral immune responses in autoimmunity.
Lu Gan +7 more
doaj +1 more source
Critical Involvement of TFIIB in Viral Pathogenesis
Frontiers in Molecular Biosciences, 2021 Viral infections and the harm they cause to their host are a perpetual threat to living organisms. Pathogenesis and subsequent spread of infection requires replication of the viral genome and expression of structural and non-structural proteins of the ...
Michael J. O’Brien, Athar Ansari
doaj +1 more source
Non-viral Gene Therapy for Osteoarthritis [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Strategies for delivering nucleic acids into damaged and diseased tissues have been divided into two major areas: viral and non-viral gene therapy. In this mini-review article we discuss the application of gene therapy for the treatment of osteoarthritis (OA), one of the most common forms of arthritis.
Ilona Uzieliene +6 more
openaire +4 more sources
Scientific Reports, 2021 In December 2019, rising pneumonia cases caused by a novel β-coronavirus (SARS-CoV-2) occurred in Wuhan, China, which has rapidly spread worldwide, causing thousands of deaths.
Lucas L. Maldonado +2 more
doaj +1 more source
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]
, 2013 Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender +117 more
core +8 more sources