Results 1 to 10 of about 6,617,451 (313)

Viral Vector-Based Gene Therapy

International Journal of Molecular Sciences, 2023
Gene therapy is a technique involving the modification of an individual’s genes for treating a particular disease. The key to effective gene therapy is an efficient carrier delivery system. Viral vectors that have been artificially modified to lose their
Xuedan Li, Yang Le, Zhegang Zhang, Xuan Nian, B. Liu, Xiaoming Yang   +5 more
semanticscholar   +3 more sources

The accessibility of the HSV genome during productive infection can vary in different cell types and affect the outcome of infection [PDF]

mBio
During productive herpes simplex virus type 1 (HSV-1) infection, the viral genome encounters a number of cellular and viral proteins, such as ICP4, which engage in processes that either attenuate or activate transcription.
Jenna M. Nosek, Sarah E. Dremel, Neal A. DeLuca   +2 more
doaj   +2 more sources

Viral evasion of intracellular DNA and RNA sensing

Nature Reviews Microbiology, 2016
The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that are adept at evading or actively suppressing host immunity.
Ying Kai Chan, Michaela U Gack
exaly   +2 more sources

Hypergraph models of biological networks to identify genes critical to pathogenic viral response [PDF]

BMC Bioinformatics, 2020
Background Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data.
Song Feng, Emily Heath, Brett Jefferson, C. Joslyn, Henry Kvinge, H. Mitchell, Brenda Praggastis, A. Eisfeld, A. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, P. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, T. Sheahan, A. Cockrell, Jacob F. Kocher, K. Stratton, Natalie C. Heller, Lisa M. Bramer, M. Diamond, R. Baric, K. Waters, Y. Kawaoka, J. Mcdermott, Emilie Purvine   +27 more
semanticscholar   +1 more source

Viral community-wide auxiliary metabolic genes differ by lifestyles, habitats, and hosts

Microbiome, 2022
Background Viral-encoded auxiliary metabolic genes (AMGs) are important toolkits for modulating their hosts’ metabolisms and the microbial-driven biogeochemical cycles.
Xiao-Qing Luo, Pandeng Wang, Jia-Ling Li, Manzoor Ahmad, Li Duan, Ling-Zi Yin, Qingling Deng, Bao-Zhu Fang, Shanhui Li, Wenjun Li   +9 more
semanticscholar   +1 more source

Diversity and potential function of pig gut DNA viruses

Heliyon, 2023
Viruses are ubiquitous in the gut of animals and play an important role in the ecology of the gut microbiome. The potential effects of these substances on the growth and development of the body are not fully known.
Junjun Qin, Bingzhen Ji, Yijia Ma, Xin Liu, Tian Wang, Guiming Liu, Bugao Li, Guoliang Wang, Pengfei Gao   +8 more
doaj   +1 more source

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways [PDF]

Nature Medicine, 2020
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and
W. Sungnak, N. Huang, C. Bécavin, M. Berg, R. Queen, Monika Litviňuková, Carlos Talavera-López, H. Maatz, D. Reichart, F. Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, J. Barnes, Nicholas E. Pascal Alvis Joseph Tushar J. Thu Elizabeth Oli Banovich Barbry Brazma Collin Desai Duong Eickelbe, N. Banovich, P. Barbry, A. Brazma, J. Collin, T. Desai, T. Duong, O. Eickelberg, C. Falk, M. Farzan, I. Glass, Ravindra K. Gupta, M. Haniffa, P. Horváth, N. Hubner, Deborah T. Hung, N. Kaminski, M. Krasnow, J. Kropski, Malte Kuhnemund, M. Lako, Haeock Lee, S. Leroy, Sten Linnarson, J. Lundeberg, K. Meyer, Zhichao Miao, A. Misharin, M. Nawijn, M. Nikolić, M. Noseda, J. Ordovas-Montañes, G. Oudit, D. Pe’er, J. Powell, S. Quake, J. Rajagopal, P. R. Tata, E. Rawlins, A. Regev, P. Reyfman, O. Rozenblatt-Rosen, K. Saeb‐Parsy, C. Samakovlis, H. Schiller, J. Schultze, M. Seibold, C. Seidman, J. Seidman, A. Shalek, D. Shepherd, J. Spence, A. Spira, Xin Sun, S. Teichmann, Fabian J Theis, Alexander M. Tsankov, L. Vallier, M. van den Berge, J. Whitsett, R. Xavier, Yan Xu, L. Zaragosi, Darin Zerti, Hongbo Zhang, Kun Zhang, M. Rojas, Francisco Figueiredo   +80 more
semanticscholar   +1 more source

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

Nature Reviews Microbiology, 2016
Aartjan J W Te Velthuis, Ervin Fodor
exaly   +2 more sources

Emerging non-viral vectors for gene delivery

Journal of Nanobiotechnology, 2023
Gene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit manipulation of gene expression.
Chenfei Wang, C. Pan, Haiyang Yong, Feifei Wang, Tao Bo, Yitong Zhao, Bin Ma, Wei He, M. Li   +8 more
semanticscholar   +1 more source

All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes

Frontiers in Immunology, 2020
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication.
Emily Yang, Melody M. H. Li
semanticscholar   +1 more source