Results 21 to 30 of about 798,219 (310)

Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family

Viruses, 2020
The genesis of gene families by the capture of host genes and their subsequent duplication is a crucial process in the evolution of large DNA viruses. CD48 is a cell surface molecule that interacts via its N-terminal immunoglobulin (Ig) domain with the ...
Pablo Martínez-Vicente, Domènec Farré, Pablo Engel, Ana Angulo   +3 more
doaj   +1 more source

Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species. [PDF]

PLoS ONE, 2014
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in the protective response to viral infection, although the precise mechanism of IFITs for reducing viral proliferation is currently unknown.
Mónica Varela, Patricia Diaz-Rosales, Patricia Pereiro, Gabriel Forn-Cuní, Maria M Costa, Sonia Dios, Alejandro Romero, Antonio Figueras, Beatriz Novoa   +8 more
doaj   +1 more source

Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]

, 2018
The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan, Liu, Fenyong, Sheng, Jingxue, Trang, Phong   +3 more
core   +5 more sources

Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]

, 2013
DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core   +2 more sources

Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes

BMC Genomics, 2011
Background Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are related human tumor viruses that cause primary effusion lymphomas (PEL) and Burkitt's lymphomas (BL), respectively.
Dresang Lindsay R, Teuton Jeremy R, Feng Huichen, Jacobs Jon M, Camp David G, Purvine Samuel O, Gritsenko Marina A, Li Zhihua, Smith Richard D, Sugden Bill, Moore Patrick S, Chang Yuan   +11 more
doaj   +1 more source

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]

, 2013
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender, A Chen, A Chen, A Le Roux, A Mor, A Rada-Iglesias, A Saha, A Sjoblom, A Smith, Aaron Arvey, Aditi Kanhere, AJ Sinclair, B Akhtar-Zaidi, B Kempkes, B Tomkinson, B Tomkinson, B Zhao, B Zhao, B Zhao, B Zhao, Bettina Kempkes, C Kaiser, C Kintner, C Subramanian, C. David Wood, CD Gregory, CF Eisenbeis, D Marshall, D Portal, D Wang, DY Wu, DY Wu, E Anderton, E Johannsen, EM Fuentes-Panana, EO Long, ES Robertson, F Lu, F Nitsche, F Wang, F Wang, F Wang, G Chinnadurai, G Laux, GL Kelly, H Ben-Bassat, Helen M. Webb, I Tempera, J O'Nions, JC Knutson, JI Cohen, JI Cohen, JI Cohen, JM Boyd, JS Knight, K Paschos, K Paschos, KG Krauer, L Skalska, L Skalska, L Waltzer, L Waltzer, L Wang, LC Spender, LC Spender, M Bain, M Bulger, M Cordier, M Hickabottom, M Wade, M Woisetschlaeger, MA Epstein, Marie L. Harth-Hertle, MB Gerstein, Michael J. McClellan, Michelle J. West, MJ Maunders, MJ McClellan, MJ West, ML Hertle, MM Pomerantz, MP Creyghton, N Ahmadiyeh, N Naumova, ND Heintzman, Opeoluwa Ojeniyi, P Nurse, PA Nikitin, Paul M. Lieberman, R Touitou, RD Palermo, RE White, RE White, Richard D. Palermo, Richard G. Jenner, S Banerjee, S Harada, S Maier, S Maruo, S Maruo, S Maruo, S Paliwal, S Tuupanen, SA Radkov, SJ Bark-Jones, SN Schlick, SR Grossman, T Choudhuri, T Henkel, Tim J. Cooper, U Schaeper, U Zimber-Strobl, VS Chopra, W Lucchesi, X Tong, X Tong, X Tong, Y Zhang   +117 more
core   +6 more sources

Diversity and potential function of pig gut DNA viruses

Heliyon, 2023
Viruses are ubiquitous in the gut of animals and play an important role in the ecology of the gut microbiome. The potential effects of these substances on the growth and development of the body are not fully known.
Junjun Qin, Bingzhen Ji, Yijia Ma, Xin Liu, Tian Wang, Guiming Liu, Bugao Li, Guoliang Wang, Pengfei Gao   +8 more
doaj  

Analysis of Global Transcriptome Change in Mouse Embryonic Fibroblasts After dsDNA and dsRNA Viral Mimic Stimulation

Frontiers in Immunology, 2019
The activation of innate immunity by viral nucleic acids present in the cytoplasm plays an essential role in controlling viral infection in both immune and non-immune cells.
Xin Xie, Pu-Ste Liu, Piergiorgio Percipalle, Piergiorgio Percipalle   +3 more
doaj   +1 more source

Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach. [PDF]

PLoS Genetics, 2010
Viruses have exerted a constant and potent selective pressure on human genes throughout evolution. We utilized the marks left by selection on allele frequency to identify viral infection-associated allelic variants.
Matteo Fumagalli, Uberto Pozzoli, Rachele Cagliani, Giacomo P Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi   +6 more
doaj   +1 more source

Viral Vectors in Gene Therapy [PDF]

Diseases, 2018
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular ...
openaire   +4 more sources