PLoS Pathogens, 2016 Subversion of host immune surveillance is a crucial step in viral pathogenesis. Epstein-Barr virus (EBV) encodes two immune evasion gene products, BCRF1 (viral IL-10) and BPLF1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune ...
Jessica McKenzie +4 more
doaj +1 more source
The Sorcerer II Global Ocean Sampling Expedition: metagenomic characterization of viruses within aquatic microbial samples. [PDF]
PLoS ONE, 2008 Viruses are the most abundant biological entities on our planet. Interactions between viruses and their hosts impact several important biological processes in the world's oceans such as horizontal gene transfer, microbial diversity and biogeochemical ...
Shannon J Williamson +11 more
doaj +1 more source
Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus [PDF]
, 2017 HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays.
Dauwe, Kenny +7 more
core +1 more source
Dietary energy drives the dynamic response of bovine rumen viral communities
Microbiome, 2017 Background Rumen microbes play a greater role in host energy acquisition than that of gut-associated microbes in monogastric animals. Although genome-enabled advancements are providing access to the vast diversity of uncultivated microbes, our ...
Christopher L. Anderson +2 more
doaj +1 more source
Gene Targeting with Viral Vectors
Molecular Therapy, 2005 Genetic manipulation of cells for scientific and therapeutic goals can be achieved by both gene-addition and gene-targeting methods. Gene targeting precisely alters a gene in its natural chromosome location, providing distinct advantages over gene-addition approaches.
Paul C. Hendrie, David W. Russell
openaire +3 more sources
Assessment of viral community functional potential from viral metagenomes may be hampered by contamination with cellular sequences [PDF]
Open Biology, 2013 Although the importance of viruses in natural ecosystems is widely acknowledged, the functional potential of viral communities is yet to be determined. Viral genomes are traditionally believed to carry only those genes that are directly pertinent to the ...
Simon Roux +4 more
doaj +1 more source
Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]
, 2013 The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin +6 more
core +3 more sources
Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
core +1 more source
PLoS Pathogens, 2019 In contrast to human cells, very few HSV-1 genes are known to be spliced, although the same pre-mRNA processing machinery is shared. Here, through global analysis of splice junctions in cells infected with HSV-1 and an HSV-1 mutant virus with deletion of
Shuang Tang +2 more
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BMC Biology, 2020 Background Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development.
Fabrice Legeai +16 more
doaj +1 more source