Efficient Protein Expression and Virus-Induced Gene Silencing in Plants Using a Crinivirus-Derived Vector. [PDF]
, 2018 Plant virus-based vectors are valuable tools for recombinant gene expression and functional genomics for both basic and applied research. In this study, Lettuce infectious yellows virus (LIYV) of the genus Crinivirus was engineered into a virus vector ...
Falk, Bryce W, Qiao, Wenjie
core +6 more sources
Virioplankton assemblages from challenger deep, the deepest place in the oceans
iScience, 2022 Summary: Hadal ocean biosphere, that is, the deepest part of the world’s oceans, harbors a unique microbial community, suggesting a potential uncovered co-occurring virioplankton assemblage.
Chen Gao +28 more
doaj +1 more source
Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. [PDF]
, 2017 External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Li, Wei +9 more
core +2 more sources
Non-viral Gene Therapy for Osteoarthritis [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Strategies for delivering nucleic acids into damaged and diseased tissues have been divided into two major areas: viral and non-viral gene therapy. In this mini-review article we discuss the application of gene therapy for the treatment of osteoarthritis (OA), one of the most common forms of arthritis.
Ilona Uzieliene +6 more
openaire +4 more sources
Dietary energy drives the dynamic response of bovine rumen viral communities
Microbiome, 2017 Background Rumen microbes play a greater role in host energy acquisition than that of gut-associated microbes in monogastric animals. Although genome-enabled advancements are providing access to the vast diversity of uncultivated microbes, our ...
Christopher L. Anderson +2 more
doaj +1 more source
Assessment of viral community functional potential from viral metagenomes may be hampered by contamination with cellular sequences [PDF]
Open Biology, 2013 Although the importance of viruses in natural ecosystems is widely acknowledged, the functional potential of viral communities is yet to be determined. Viral genomes are traditionally believed to carry only those genes that are directly pertinent to the ...
Simon Roux +4 more
doaj +1 more source
Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]
, 2019 Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet +4 more
core +1 more source
Viral gene drive in herpesviruses [PDF]
Nature Communications, 2019 AbstractHerpesviruses are ubiquitous pathogens in need of novel therapeutic solutions. Current engineered gene drive strategies rely on sexual reproduction, and are thought to be restricted to sexual organisms. Here, we report on the design of a novel gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in ...
Walter, Marius, Verdin, Eric
openaire +3 more sources
PLoS Pathogens, 2019 In contrast to human cells, very few HSV-1 genes are known to be spliced, although the same pre-mRNA processing machinery is shared. Here, through global analysis of splice junctions in cells infected with HSV-1 and an HSV-1 mutant virus with deletion of
Shuang Tang +2 more
doaj +1 more source
Complete genome viral phylogenies suggests the concerted evolution of regulatory cores and accessory satellites. [PDF]
PLoS ONE, 2008 We consider the concerted evolution of viral genomes in four families of DNA viruses. Given the high rate of horizontal gene transfer among viruses and their hosts, it is an open question as to how representative particular genes are of the evolutionary ...
Paolo Marinho de Andrade Zanotto +1 more
doaj +1 more source