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Progress of sex control techniques in mammals†. [PDF]

Biol Reprod
Chen H, Rushdi HE, Loor JJ, Teng Z, Liu S.   +4 more
europepmc   +1 more source

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Sry and Sox9: mammalian testis-determining genes

Cellular and Molecular Life Sciences, 1999
Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin.
Peter A Koopman
exaly   +4 more sources

Rapid sequence evolution of the mammalian sex-determining gene SRY

Nature, 1993
In mammals, induction of male sex determination requires the Y-chromosome gene SRY. SRY encodes a protein with a central 'high mobility group' domain (HMG box) of about 78 amino acids. HMG boxes are found in a wide variety of proteins that bind to DNA with high affinity but differing degrees of sequence specificity.
Robin Lovell-Badge
exaly   +3 more sources

Interactions between SRY and SOX genes in mammalian sex determination

BioEssays, 1998
The SRY gene on the mammalian Y chromosome undoubtedly acts to determine testis, but it is still quite unclear how. It was originally supposed that SRY acts directly to activate other genes in the testis-determining pathway. This paper presents an alternative hypothesis that SRY functions indirectly, by interacting with related genes SOX3 (from which ...
Jenny Graves
exaly   +3 more sources

SRY-related genes in Xenopus oocytes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996
SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-
S, Miyata, K, Miyashita, Y, Hosoyama
openaire   +2 more sources

SRY – o gene da determinação sexual

Genética na Escola, 2023
O processo de determinação sexual em humanos começa muito antes do nascimento; é na concepção que o sexo cromossômico é determinado: XX ou XY. No cromossomo Y está presente o fator de determinação sexual: o gene SRY. Este gene de apenas um éxon desencadeia uma cascata de processos que envolve muitos outros genes e sua expressão pode ser detectada ainda
openaire   +1 more source

A novel Xenopus laevis SRY-related gene, xSox33

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003
The sex-determining region Y (SRY) gene and its related Sox genes encode transcriptional regulatory factors. In this study, we isolated and sequenced a novel Sox cDNA from African clawed frog (Xenopus laevis). The Sox gene was named xSox33. xSox33 was revealed to encode 244 amino acids.
Jun, Hagiuda, Yoshiki, Hiraoka, Masanori, Hasegawa, Motoyuki, Ogawa, Sadakazu, Aiso   +4 more
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Regulation of tyrosine hydroxylase gene transcription by Sry

Neuroscience Letters, 2004
Testes determining factor Sry is encoded by the Sry locus on the Y chromosome and may be involved in the regulation of blood pressure. Here we tested the hypothesis that Sry regulates transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines. Sry was found to be expressed in catecholaminergic regions, in
Amy, Milsted, Lidia, Serova, Esther L, Sabban, Gail, Dunphy, Monte E, Turner, Daniel L, Ely   +5 more
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