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A Dual-Purpose Non-Canonical Amino Acid for the Expanded Genetic Code: Combining Metal-Binding and Click Chemistry. [PDF]

Angew Chem Int Ed Engl
Day GJ, Zaytsev AV, Brewster RC, Kozhevnikov VN, Jarvis AG.   +4 more
europepmc   +1 more source

A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli

Zhang J, Yu K, Xu Y, Zhao W, Li Y, Wang Y, Seebeck FP, Chen X, Liao C.   +8 more
europepmc   +1 more source

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Genetic Code Expansion: Inception, Development, Commercialization.

Journal of the American Chemical Society, 2021
Virtually all natural proteins are built from only 20 amino acids, and while this makes possible all the functions they perform, the ability to encode other amino acids selected for specific purposes promises to enable the discovery and production of ...
Miglena Manandhar, E. Chun, F. Romesberg
semanticscholar   +1 more source

Genetic Code

Encyclopedia of Gerontology and Population Aging, 2021
openaire   +2 more sources

Prokaryotic genetic code

Experientia, 1990
The prokaryotic genetic code has been influenced by directional mutation pressure (GC/AT pressure) that has been exerted on the entire genome. This pressure affects the synonymous codon choice, the amino acid composition of proteins and tRNA anticodons.
S, Osawa, A, Muto, T, Ohama, Y, Andachi, R, Tanaka, F, Yamao   +5 more
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Evolution of the genetic code: The ambiguity-reduction theory

Biosyst., 2019
The experimental evidence has shown that the genetic code is based on arbitrary, or conventional, rules, in the sense that any codon can be associated to any amino acid, and this means that there is no deterministic link between them.
M. Barbieri
semanticscholar   +1 more source

Expanding the genetic code

Chemical Communications, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lei, Wang, Peter G, Schultz
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Genetic coding theory: Multiple mitochondrial genetic codes

International Journal of Quantum Chemistry, 1984
The generalized genetic code is applied to alternative codings recently derived from studies of mitochondrial protein synthesis. It is argued that mitochondrial protein synthesis is comprised of a class of biological contexts, rather than a single biological context, and that there exist, therefore, multiple mitochondrial genetic codes.
A. M. Findley, G. L. Findley
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The Genetic Code

Scientific American, 1962
(a) The nature of the problem Genes are made of nucleic acid. Enzymes are made of protein. The amino acid sequence of a particular protein is synthesized under instruction from a particular piece of nucleic acid. Each protein is made of one or more polypeptide chains, synthesized by con?
openaire   +2 more sources