Results 51 to 60 of about 4,608,949 (263)
Directed evolution of rRNA improves translation kinetics and recombinant protein yield
Nature Communications, 2021 Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.
Fan Liu +4 more
doaj +1 more source
Phospho-Form Specific Substrates of Protein Kinase B (AKT1)
Frontiers in Bioengineering and Biotechnology, 2021 Protein kinase B (AKT1) is hyper-activated in diverse human tumors. AKT1 is activated by phosphorylation at two key regulatory sites, Thr308 and Ser473. Active AKT1 phosphorylates many, perhaps hundreds, of downstream cellular targets in the cytosol and ...
McShane McKenna +5 more
doaj +1 more source
Molecules, 2022 The expression of genes of interest (GOI) can be initiated by providing external stimuli such as temperature shifts and light irradiation. The application of thermal or light stimuli triggers structural changes in stimuli-sensitive biomolecules within ...
Jongdoo Choi +3 more
doaj +1 more source
Viruses, 2022 Despite many efforts and diverse approaches, developing an effective herpesvirus vaccine remains a great challenge. Traditional inactivated and live-attenuated vaccines always raise efficacy or safety concerns. This study used Pseudorabies virus (PRV), a
Tong-Yun Wang +11 more
doaj +1 more source
Genetic Code Expansion System for Tight Control of Gene Expression in Bombyx mori Cell Lines
Insects, 2021 Inducible gene expression systems are important tools for studying gene function and to control protein synthesis. With the completion of the detailed map of the silkworm (Bombyx mori) genome, the study of Bombyx mori has entered the post-genome era ...
Wei Lu +4 more
doaj +1 more source
Towards programmable metallonucleases via genetic code expansion
Frontiers in Chemical BiologyThe rapid advancement of protein engineering and genetic code expansion technologies over the last decade has reshaped how researchers rationally design proteins with novel catalytic functions.
Eryn Lundrigan +2 more
doaj +1 more source
eLife, 2021 Synthetic strategies for optically controlling gene expression may enable the precise spatiotemporal control of genes in any combination of cells that cannot be targeted with specific promoters.
Lloyd Davis +8 more
doaj +1 more source
Graphical representation of genetic code algebra [PDF]
, 2023 During the translation process, the genetic code is the nucleotide sequence that determines the amino acid sequence of protein molecules. A codon is a universal triplet of nucleotides that codes for an amino acid. A group G's identity graph is a graph in
Birinchi Kumar Boruah, Tazid Ali
core +1 more source
Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine +17 more
wiley +1 more source
Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life
Life, 2016 The origins of the components of genetic coding are examined in the present study. Genetic information arose from replicator induction by metabolite in accordance with the metabolic expansion law.
J. Tze-Fei Wong +4 more
doaj +1 more source