Results 41 to 50 of about 4,608,949 (263)
Versatility of Synthetic tRNAs in Genetic Code Expansion [PDF]
Genes, 2018 Transfer RNA (tRNA) is a dynamic molecule used by all forms of life as a key component of the translation apparatus. Each tRNA is highly processed, structured, and modified, to accurately deliver amino acids to the ribosome for protein synthesis. The tRNA molecule is a critical component in synthetic biology methods for the synthesis of proteins ...
Kyle S. Hoffman +2 more
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A novel differential evolution algorithmic approach to transmission expansion planning [PDF]
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Nowadays modern electric power systems consist of large-scale and highly complex interconnected transmission systems, thus transmission expansion planning ...
Sum-Im, Thanathip
core +7 more sources
Applications of genetic code expansion technology in eukaryotes. [PDF]
Protein Cell, 2023 Abstract Unnatural amino acids (UAAs) have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to proteins. In eukaryotes, genetic code expansion (GCE) enables the incorporation of UAAs and facilitates posttranscriptional modification (PTM), which is ...
Guo QR, Cao YJ.
europepmc +3 more sources
Synthesis at the interface of virology and genetic code expansion [PDF]
Current Opinion in Chemical Biology, 2018 How a virus efficiently invades its host cell and masterfully engineers its properties provides valuable lessons and resources for the emerging discipline of synthetic biology, which seeks to create engineered biological systems with novel functions.
Rachel E, Kelemen +2 more
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Pyrrolysyl-tRNA Synthetase, an Aminoacyl-tRNA Synthetase for Genetic Code Expansion
Croatica Chemica Acta, 2016 Genetic code expansion (GCE) has become a central topic of synthetic biology. GCE relies on engineered aminoacyl‐tRNA synthetases (aaRSs) and a cognate tRNA species to allow codon reassignment by co-translational insertion of non-canonical amino acids ...
Ana Crnković +3 more
doaj +1 more source
Frontiers in Microbiology, 2020 Due to the rapid emergence of multi-resistant bacterial strains in recent decades, the commercially available effective antibiotics are becoming increasingly limited.
Hamid Reza Karbalaei-Heidari +3 more
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Designing efficient genetic code expansion in Bacillus subtilis to gain biological insights
Nature Communications, 2021 B. subtilis is valuable both as a model for cell biology and as an industrial organism. Here the authors use genetic code expansion to enable functional tools for exploring cell division dynamics.
Devon A. Stork +9 more
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Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion. [PDF]
Angew Chem Int Ed EnglWilliams TL +8 more
europepmc +2 more sources
Measuring the tolerance of the genetic code to altered codon size
eLife, 2022 Translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet codon, rather than quadruplet codon, genetic code?
Erika Alden DeBenedictis +2 more
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Frontiers in Pharmacology, 2019 The translation system is a sophisticated machinery that synthesizes proteins from 20 canonical amino acids. Recently, the repertoire of such composition has been expanded by the introduction of non-canonical amino acids (ncAAs) with the genetic code ...
Sumana Venkat +4 more
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