Results 61 to 70 of about 273,398 (272)
Genetic Code Expansion and Bio-Orthogonal Labeling Reveal Intact HIV-1 Capsids inside the Nucleus
mBio, 2022 Microscopy is one of the few techniques that can directly observe the HIV-1 capsid as it traverses the cell. However, an extrinsic or intrinsic label is needed to facilitate detection and this can perturb capsid behavior. Now, S. Schifferdecker, V. Zila,
Leo C. James
doaj +1 more source
Intellectual Property and Opportunities for Food Security in the Philippines [PDF]
, 2013 By 2050, the Philippine population is projected to increase by as much as 41 percent, from 99.9 million to nearly 153 million people. Producing enough food for such an expanding population and achieving food security remain a challenge for the Philippine
Alfonso, Antonio +6 more
core +3 more sources
Frontiers in Synaptic Neuroscience, 2021 Fluorescence labeling of difficult to access protein sites, e.g., in confined compartments, requires small fluorescent labels that can be covalently tethered at well-defined positions with high efficiency.
Alexander Kuhlemann +12 more
doaj +1 more source
Inverse relationship between genetic diversity and epigenetic complexity [PDF]
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Simplified methodology for a modular and genetically expanded protein synthesis in cell-free systems
Synthetic and Systems Biotechnology, 2019 Genetic code expansion, which enables the site-specific incorporation of unnatural amino acids into proteins, has emerged as a new and powerful tool for protein engineering.
Yonatan Chemla +5 more
doaj +1 more source
eLife, 2021 Type three secretion systems enable bacterial pathogens to inject effectors into the cytosol of eukaryotic hosts to reprogram cellular functions. It is technically challenging to label effectors and the secretion machinery without disrupting their ...
Moirangthem Kiran Singh +3 more
doaj +1 more source
Three phases in the evolution of the standard genetic code: how translation could get started [PDF]
, 2007 A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like.
van der Gulik, Peter
core +1 more source
p-Adic Modelling of the Genome and the Genetic Code
, 2007 The present paper is devoted to foundations of p-adic modelling in genomics. Considering nucleotides, codons, DNA and RNA sequences, amino acids, and proteins as information systems, we have formulated the corresponding p-adic formalisms for their ...
Dragovich, Alexandra, Dragovich, Branko
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Phylogenetic and phenotypic divergence of an insular radiation of birds [PDF]
, 2010 Evolutionary divergence of lineages is one of the key mechanisms underpinning large scale patterns in biogeography and biodiversity. Island systems have been highly influential in shaping theories of evolutionary diversification and here I use the ...
Black, Richard Anthony +1 more
core +1 more source