Results 221 to 230 of about 1,122,121 (342)

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Genetic Correlation and Mendelian Randomization Analysis Revealed an Unidirectional Causal Relationship Between Left Caudal Middle Frontal Surface Area and Cigarette Consumption. [PDF]

Psychiatry Investig
Xie H, Wang A, Yu M, Wang T, Liang X, He R, Huang C, Lei W, Chen J, Tan Y, Liu K, Xiang B.   +11 more
europepmc   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Genetic correlation between fetal nuchal translucency thickening and cystic hygroma and exploration of pregnancy outcome. [PDF]

Sci Rep
Zheng J, Wang T, Sun H, Guan Y, Yang F, Wu J, Ying F, Fu Y, Li M, Liu J.   +9 more
europepmc   +1 more source

Heritabilities and genetic correlations for birth weight, weaning weight, and yearling weight in polled Hereford cattle

, 1994
J.B. Glaze, R.R. Schalles
openalex   +2 more sources

Correlation of Morphologic and Cytogenetic Parameters of Genetic Instability With Chromosomal Alterations in In Situ Carcinomas of the Breast [PDF]

, 2000
Horst Buerger, Ellen C.M. Mommers, Ruth Littmann, Raihanatou Diallo, C. Brinkschmidt, Christopher Poremba, Barbara Dockhorn‐Dworniczak, P. J. van Diest, W. Böcker   +8 more
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The Causal Relationship Between Gut Microbiomes, Inflammatory Mediators, and Traumatic Brain Injury in Europeans: Evidence from Genetic Correlation and Functional Mapping Annotation Analyses. [PDF]

Biomedicines
Song B, Qiu Y, Wang Z, Tao Y, Wang M, Duan A, Xie M, Yin Z, Chen Z, Ma C, Wang Z.   +10 more
europepmc   +1 more source

Autosomal dominant polycystic kidney disease—type 2. Ultrasound, genetic and clinical correlations [PDF]

, 2000
Kyproulla Demetriou, Chrysa Tziakouri, Kristiana Anninou, Andri Eleftheriou, Michalis Koptides, Alexia Nicolaou, Constantinos Deltas, Alkis Pierides   +7 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source