Results 181 to 190 of about 6,543,071 (370)

The pursuit of genetic gain in agricultural crops through the application of machine-learning to genomic prediction. [PDF]

Front Genet, 2023
Jones D, Fornarelli R, Derbyshire M, Gibberd M, Barker K, Hane J.   +5 more
europepmc   +1 more source

Advanced optimization of gas turbine aero-engine transient performance using linkage-learning genetic algorithm: Part II, optimization in flight mission and controller gains correlation development

, 2020
Yinfeng Liu, Soheil Jafari, Theoklis Nikolaidis   +2 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Population improvement via recurrent selection drives genetic gain in upland rice breeding. [PDF]

Heredity (Edinb), 2023
Pereira de Castro A, Breseghello F, Furtini IV, Utumi MM, Pereira JA, Cao TV, Bartholomé J.   +6 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Simulations of rate of genetic gain in dry bean breeding programs. [PDF]

Theor Appl Genet, 2023
Lin J, Arief V, Jahufer Z, Osorno J, McClean P, Jarquin D, Hoyos-Villegas V.   +6 more
europepmc   +1 more source

Supplementary Table 3 from A Genetic Screen to Identify Gain- and Loss-of-Function Modifications that Enhance T-cell Infiltration into Tumors

, 2023
Laura M. Rogers, Zhaoming Wang, Sarah L. Mott, Adam J. Dupuy, George J. Weiner   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Defining Multi-Trait Breeding Objectives and Selection Indexes to Develop More Efficient Breeding Programs for Superfine Wool Sheep

Animals
This study aimed to develop an optimized breeding program for the Alpine Merino sheep superfine strain by defining breeding objectives and establishing a multi-trait selection index. Using phenotypic and genetic (co)variance components of wool and growth
Tingting Guo, Wenhui Li, Chao Yuan, Xijun Wang, Jianbin Liu, Bin Liang   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source