Results 191 to 200 of about 5,638,229 (338)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Imputation of non-genotyped F1 dams to improve genetic gain in swine crossbreeding programs. [PDF]

J Anim Sci, 2022
See GM, Fix JS, Schwab CR, Spangler ML.
europepmc   +1 more source

Potential Genetic Gains from Producing Bulls with Only Sires as Parents

, 1985
P. M. van Raden, A.E. Freeman
openalex   +1 more source

Maximizing genetic gain over multiple generations with quantitative trait locus selection and control of inbreeding1 [PDF]

, 2004
Beatriz Villanueva, Jack C. M. Dekkers, John Woolliams, P. Settar   +3 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The Effect of Using Organic or Conventional Sires on Genetic Gain in Organic Pigs: A Simulation Study. [PDF]

Animals (Basel), 2022
Zaalberg RM, Nielsen HM, Sørensen AC, Chu TT, Jensen J, Villumsen TM.   +5 more
europepmc   +1 more source

Selection and genetic gains for juvenile traits in progenies of Hevea in São Paulo State, Brazil [PDF]

, 2004
Paulo de Souza Gonçalves, Antônio Lúcio Mello Martins, Nelson Bortoletto, Luís Alberto Sáes   +3 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Gaining Ground in the Genetics of Gastric Cancer [PDF]

Gastroenterology, 2017
openaire   +3 more sources

Early Realized Genetic Gains for Coastal Douglas-Fir in the Northern Oregon Cascades [PDF]

, 2004
J. Bradley St. Clair, Nancy L. Mandel, K. J. S. Jayawickrama   +2 more
openalex   +1 more source