Results 211 to 220 of about 7,102,789 (361)

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study. [PDF]

Health Sci Rep
Bi J, Liu A, Zhang N, Chen Y, Liu C, Zhu Y, Wen H, Ma C.   +7 more
europepmc   +1 more source

The intervertebral discs' fibrocartilage as a DNA source for genetic identification in severely charred cadavers. [PDF]

Forensic Sci Med Pathol, 2022
Tomsia M, Droździok K, Banaszek P, Szczepański M, Pałasz A, Chełmecka E.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genetic identification and characterization of novel loci for flag leaf morphology traits in Chinese endemic wheat. [PDF]

Plant Genome
Lohani MN, Su L, Lu L, Yin L, Liu Y, Xu Q, Jiang Y, Jiang Q, Chen G, Wei Y, Liu C, Xie Q, Ma J.   +12 more
europepmc   +1 more source

A computational approach for positive genetic identification and relatedness detection from low-coverage shotgun sequencing data. [PDF]

J Hered, 2023
Nguyen R, Kapp JD, Sacco S, Myers SP, Green RE.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genetic identification of Pid3-1 and its regulatory role in promoting blast resistance in rice. [PDF]

G3 (Bethesda)
Liu J, He N, Cheng Z, Lin S, Fu S, Wang M, Huang F, Abou-Elwafa SF, Al Aboud NM, Huang C, Yang D.   +10 more
europepmc   +1 more source

Morphological, acoustic and genetic identification of a reproducing population of the invasive African clawed frog Xenopuslaevis (Anura, Pipidae) recently discovered in Belgium. [PDF]

Zookeys, 2023
Pauwels OSG, Brecko J, Baeghe D, Venderickx J, Vanderheyden A, Backeljau T.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia. [PDF]

Cell Rep
Li T, Son H, Arora V, Shannonhouse J, Kumari S, Chang D, Caterina M, Kim YS, Chung MK.   +8 more
europepmc   +1 more source