Results 81 to 90 of about 5,764,173 (258)

The challenge of detecting epistasis (G×G Interactions): Genetic Analysis Workshop 16 [PDF]

, 2009
Interest is increasing in epistasis as a possible source of the unexplained variance missed by genome-wide association studies. The Genetic Analysis Workshop 16 Group 9 participants evaluated a wide variety of classical and novel analytical methods for ...
Mariza de Andrade, Corinne D. Engelman, Chien‐Hsun Huang, Li Yao, de Andrade, Mariza, An, Ping, Dube, Marie-Pierre, Pritam Chanda, Ping An, Clarke, Geraldine M., Manning, Alisa K., Jung, Jeesun, Engelman, Corinne D., Doerthe Malzahn, Tian Zheng, Zheng, Tian, Yao, Li, Mukherjee, Odity, Huang, Chien-Hsun, Michael A. Province, Jia Li, Geraldine M. Clarke, Yao, L. I., Kovac, Ilija P., Odity Mukherjee, Marie‐Pierre Dubé, Malzahn, Doerthe, Jeesun Jung, Liang, Xueying, Chanda, Pritam, Li, Jia, Alisa K. Manning, Xueying Liang, Province, Michael A., Ilija P. Kovac, Robert Culverhouse, Culverhouse, Robert   +36 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Using Zebrafish to Study Multiciliated Cell Development and Disease States

Cells
Multiciliated cells (MCCs) serve many important functions, including fluid propulsion and chemo- and mechanosensing. Diseases ranging from rare conditions to the recent COVID-19 global health pandemic have been linked to MCC defects. In recent years, the
Thanh Khoa Nguyen, Sophia Baker, John-Michael Rodriguez, Liana Arceri, Rebecca A. Wingert   +4 more
doaj   +1 more source

Condition‐specific genetic interaction maps reveal crosstalk between the cAMP/PKA and the HOG MAPK pathways in the activation of the general stress response

Molecular Systems Biology, 2015
Cells must quickly respond and efficiently adapt to environmental changes. The yeast Saccharomyces cerevisiae has multiple pathways that respond to specific environmental insults, as well as a generic stress response program.
Jenia Gutin, Amit Sadeh, Ayelet Rahat, Amir Aharoni, Nir Friedman   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Resolving the infection process reveals striking differences in the contribution of environment, genetics and phylogeny to host-parasite interactions [PDF]

, 2011
Background Infection processes consist of a sequence of steps, each critical for the interaction between host and parasite. Studies of host-parasite interactions rarely take into account the fact that different steps might be influenced by different ...
Ebert, Dieter, Dieter Ebert, Ben-Ami, Frida, Laforsch Christian, Duneau David, Ebert Dieter, David Duneau, Laforsch, C., Luijckx Pepijn, Duneau, David, Luijckx, P., Ben-Ami, F., Luijckx, Pepijn, Frida Ben-Ami, Pepijn Luijckx, Duneau, D., Ben-Ami Frida, Christian Laforsch, Laforsch, Christian   +18 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Interactions of genetic and environmetal factors in chronic obstructive pulmonary disease

, 2019
Chronic obstructive pulmonary disease (COPD) is featured by abnormal inflammatory response of the lungs to toxic particles or gases, such as cigarette smoke.
Stanković, Marija, Dragica, Radojković
core  

Genetic architecture of rainbow trout survival from egg to adult [PDF]

, 2010
Survival from birth to a reproductive adult is a challenge that only robust individuals resistant to a variety of mortality factors will overcome. To assess whether survival traits share genetic architecture throughout the life cycle, we estimated ...
Paananen, T., Quiton, C., Vehvilainen, H., Kuukka-Anttila, H., Koskinen, H., Kause, A.   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source