Results 141 to 150 of about 1,985,505 (274)

The relationship between emotional disorders and heart rate variability: A Mendelian randomization study.

PLoS ONE
ObjectivePrevious studies have shown that emotional disorders are negatively associated with heart rate variability (HRV), but the potential causal relationship between genetic susceptibility to emotional disorders and HRV remains unclear.
Xu Luo, Rui Wang, YunXiang Zhou, Wen Xie
doaj   +1 more source

A new direction for farm animal genetic resources [PDF]

, 2009
In September 2007, the International Technical Conference on Animal Genetic Resources for Food and Agriculture was held in Interlaken, Switzerland. Two important documents aiming at preventing the genetic erosion of farm animal biodiversity and promoting
Kantanen, Juha
core  

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao, Gabriel Chun Yin Sung, Yiwen Liang, Chenxi Li, Shiu Lun Au Yeung   +4 more
wiley   +1 more source

Cross-trait genetic enrichment between GERD and psychiatric disorders in East Asian populations

Frontiers in Genetics
Gastroesophageal reflux disease (GERD) exhibits significant epidemiological comorbidity with psychiatric disorders, yet their shared genetic architecture remains poorly characterized in East Asian populations.
Zhihao Gao, Xianjin Wang, Zekun Liu, Fen Hu, Yidi Zhou, Kalim Ullah, Ruiwei Wang, Meng Zhang, Xiao Chang, Yongsen Wang, Yongsen Wang   +10 more
doaj   +1 more source

Microbiome‐mediated immunity: Limited support from the gazelle dung beetle

Ecological Entomology, EarlyView.
Digitonthophagus gazella rely on a maternally inherited microbiome passed across generations via a maternal faecal pellet called the pedestal. We experimentally manipulated the presence of the pedestal, providing it to some individuals while withholding it from others to determine how pedestal microbiota may affect beetle immune potential.
Joshua A. Jones, Irene L. G. Newton, Armin P. Moczek   +2 more
wiley   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies

BMC Genomics
Background Analyses of a bipartite Genotype and Phenotype Network (GPN), linking the genetic variants and phenotypes based on statistical associations, provide an integrative approach to elucidate the complexities of genetic relationships across diseases
Xuewei Cao, Lirong Zhu, Xiaoyu Liang, Shuanglin Zhang, Qiuying Sha   +4 more
doaj   +1 more source

A conundrum of pleiotropy: GWAS-derived pleiotropy is weakly negatively associated with co-expression network centrality in Arabidopsis thaliana

Pleiotropy, the influence of a single gene on multiple phenotypic traits, is a fundamental feature of genetic systems but remains difficult to quantify at genome-wide scales.
Samuel Yeaman, Chatendeep Gill
core   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source