Journal of Diabetes Investigation, EarlyView.Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen +6 more
wiley +1 more source
Beyond the Management Gene: Rethinking and Advancing the Genetic Perspective in Management
Journal of Management Studies, EarlyView.Abstract Genetics has emerged as a promising avenue for explaining differences in management outcomes, attracting attention from leadership, entrepreneurship, and organizational behaviour scholars. Nonetheless, the field has faced scepticism and made only limited progress, stagnating in the pursuit of a so‐called ‘management gene’ (e.g., leadership ...
Ahmed Maged Nofal, Marcus Wolfe
wiley +1 more source
Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma: An Integrated Proteogenomic Investigation. [PDF]
Children (Basel)Chen L +8 more
europepmc +1 more source
A Principled Framework for Mendelian Randomization in Oral Health Research
Journal of Periodontal Research, EarlyView.This methodological article provides a clear and accessible overview of Mendelian randomization for oral health researchers, emphasizing the core assumptions needed for credible causal inference. Focusing on applications in oral health, particularly periodontitis, it highlights both the strengths and limitations of the study design in order to support ...
Nasir Z. Bashir +5 more
wiley +1 more source
A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density. [PDF]
BoneHan T +17 more
europepmc +1 more source
Genetic Susceptibility to Periodontitis
Journal of Periodontal Research, EarlyView.Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley +1 more source
Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. [PDF]
J Transl MedJiang X +5 more
europepmc +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis. [PDF]
Invest Ophthalmol Vis SciGao Y +11 more
europepmc +1 more source
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source