Results 171 to 180 of about 1,985,505 (274)

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. [PDF]

Nat Hum Behav
Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC.   +12 more
europepmc   +1 more source

Editorial: Establishing Genetic Pleiotropy to Identify Common Pharmacological Agents for Common Diseases. [PDF]

Front Pharmacol, 2019
O'Mara TA, Batra J, Glubb D.
europepmc   +1 more source

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy. [PDF]

Lab Invest, 2019
Chornenkyy Y, Fardo DW, Nelson PT.
europepmc   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

PDGFRA::USP8 Fusion in a Cutaneous Inflammatory Myofibroblastic Tumor, Highlighting Genetic Pleiotropy of Kinase Gene Fusions in Soft Tissue Neoplasms. [PDF]

Genes Chromosomes Cancer
Vernemmen AIP, van Kempen LCLT, Aarts F, Zur Hausen A, Sciot RME, Hornick JL, van den Hout MFCM.   +6 more
europepmc   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Periodontitis, Edentulism, and Risk of Inflammatory Bowel Disease (IBD): A Systematic Review With Meta‐Analysis

Journal of Periodontal Research, EarlyView.
This systematic review with meta‐analyzes evaluated the relationship between periodontitis, severe periodontitis, edentulism, and inflammatory bowel disease (IBD). While longitudinal studies suggested a modest association mainly with ulcerative colitis, cross‐sectional evidence consistently supported the coexistence of periodontal disease and IBD ...
Mario Aimetti, Giacomo Tonello, Vivek Thumbigere‐Math, Davide Giuseppe Ribaldone, Mario Romandini, Federica Romano, Giacomo Baima   +6 more
wiley   +1 more source

Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree. [PDF]

Transl Psychiatry, 2018
Kember RL, Hou L, Ji X, Andersen LH, Ghorai A, Estrella LN, Almasy L, McMahon FJ, Brown C, Bućan M.   +9 more
europepmc   +1 more source

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Pleiotropy and the Increasing Complexity of Parkinson's Disease Genetics

Annals of Neurology
Jonggeol, Kim, Joshua M, Shulman
openaire   +2 more sources