Results 151 to 160 of about 1,985,505 (274)

Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Finnish Ayrshire cattle belong to the Nordic Red breeds. The basis of selection in Nordic Red breeds shifted from traditional pedigree‐based breeding values to genomic breeding values between 2011 and 2014. Joint genetic evaluation and admixture among the Nordic Red breeds have led to the formation of a composite Nordic Red population ...
Katri Sarviaho, Minna Koivula, Terhi Iso‐Touru, Pekka Uimari, Katja Hänninen   +4 more
wiley   +1 more source

Genetic Evaluation for Functional Longevity in Nellore Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Stayability (STAY) presents limitations in capturing genetic variability among animals with varying calving records up to 76 months of age. Furthermore, because STAY is measured late in life (typically at 6 years of age), it inherently prolongs generation intervals.
Gabriele de Souza Silva Fernandes, Dalila Ribeiro dos Santos, Arione Augusti Boligon, Mário Luiz Santana, Gilberto Romeiro de Oliveira Menezes, Denise Rocha Ayres, Annaiza Braga Bignardi, Rodrigo Junqueira Pereira   +7 more
wiley   +1 more source

Genetic Pleiotropy in Depression and Coronary Artery Disease [PDF]

Psychosomatic Medicine, 2006
openaire   +2 more sources

Unraveling Biotypes Related to Thermotolerance During Lactation in Maternal‐Line Pigs Through Principal Component and Factor Analyses

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Heat stress imposes significant challenges to welfare, health, and productivity of lactating sows due to their limited thermoregulatory capacity and increased metabolic heat load. Genetic selection for improved heat tolerance is a promising yet complex approach, given the large number of biological processes involved in heat stress response ...
Cassiane Gomes dos Santos, Renata Veroneze, Artur O. Rocha, Hinayah Rojas de Oliveira, Letícia Fernanda de Oliveira, Jay S. Johnson, Pedro H. F. Freitas, Hui Wen, Allan P. Schinckel, Luiz F. Brito   +9 more
wiley   +1 more source

Genetic and Phenotypic Correlations Among Growth, Disease Occurrence, and Reproductive Performance From Calf to Heifer in Girolando Dairy Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Girolando breed, a cross between Holstein (Bos taurus) and Gir (Bos indicus), is the primary choice for dairy production in Brazilian tropical regions, as it combines high productive potential with adaptation to the tropical environment.
Laura B. da C. Pereira, Viviane A. Ligori, Hinayah R. de Oliveira, Eula R. Carrara, Carolina A. de S. D. Muniz, Edson L. de A. Ribeiro, Lenira E. F. Zadra   +6 more
wiley   +1 more source

Exploring pleiotropy in Mendelian randomisation analyses:What are genetic variants associated with “cigarette smoking initiation” really capturing?

Genetic variants used as instruments for exposures in Mendelian randomisation (MR) analyses may have horizontal pleiotropic effects (i.e., influence outcomes via pathways other than through the exposure), which can undermine the validity of results.
Wootton, Robyn E, Sanderson, Eleanor C M, Davey Smith, George, Reed, Zoe E, Khouja, Jasmine N, Munafo, Marcus R, Richardson, Tom G   +6 more
core   +1 more source

Single‐Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. It reduces quality of life and increases the risk of complications such as stroke. Although progress has been made in understanding its pathogenesis, the key cellular subtypes and therapeutic targets remain unclear. Methods We applied single‐cell transcriptomics
Xiangpeng Chen, Hongquan Chen, Shiguang Xu, Shumin Wang, Huishan Wang, Hao Meng   +5 more
wiley   +1 more source

Polygenic Risk Modelling in Periodontitis: Insights From a Feasibility Study of 4243 European Cases and Current Limitations

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Aim Genetic susceptibility plays a particularly important role in early‐onset (EO) and severe periodontitis (PD). The genetic risk remains largely unexplained because of limited sample sizes and heterogeneous phenotypes in genome‐wide association studies (GWAS).
Gesa M. Richter, O. Mercy Akinloye, M. Kamal Nasr, Birte Holtfreter, Alicia de Coo, Silvia Diz De Almeida, Bruno G. Loos, Søren Jepsen, Henrik Dommisch, Corinna Bruckmann, Ines Kapferer‐Seebacher, PerioGEN Cohort Group, Georg Homuth, Thomas Kocher, Henry Völzke, Klaus Berger, Matthias Laudes, Wolfgang Lieb, Nathalie van der Velde, Natasja van Schoor, Lisette de Groot, Juan Blanco, Angel Carracedo, Raquel Cruz, Astrid Dempfle, Alexander Teumer, Arne S. Schaefer, Sandra Freitag‐Wolf   +27 more
wiley   +1 more source

Disentangling direct and indirect genetic pathways to neurodevelopmental risk: brain structure and behavior in a population‐based parent–offspring trio study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Neurodevelopmental disorders (NDDs) are highly heritable, yet the pathways linking parental genetic liability to child outcomes remain poorly understood. Traditional designs cannot easily separate genes transmitted to the child from environmental influences shaped by parental genotypes.
Fin J. E. van Uum, Yllza Xerxa, Alexander Neumann, Jean‐Baptiste Pingault, Charlotte A. M. Cecil, Mina Shahisavandi, Koen Bolhuis, Boglarka Kovacs, Henning Tiemeier, Ryan L. Muetzel, Neeltje E. M. van Haren   +10 more
wiley   +1 more source

Partitioning genetic pleiotropy within tissue-specific regulatory patterns. [PDF]

Cell Genom
Panja P, Biswas D, Bhattacharjee S.
europepmc   +1 more source