Results 211 to 220 of about 1,985,505 (274)

Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation – ‘MR Fish’

Warwick AN, Hingorani AD, Khawaja AP, Gordillo-Marañón M, Olvera-Barrios A, Stuart KV, Egan C, Tufail A, Sofat R, Kuan Po Ai V, Finan C, Schmidt AF.   +11 more
europepmc   +1 more source

Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes. [PDF]

Brief Bioinform
Wu X, Yan Y, Cao W, Wu T, He J, Wang D, Gong J, Niu X.   +7 more
europepmc   +1 more source

Student–teacher relationships as a mediator of children's education‐linked genetics: results from the Norwegian Mother, Father and Child Cohort Study

Journal of Child Psychology and Psychiatry, Volume 67, Issue 10, Page 1729-1740, October 2026.
Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry, Elizabeth C. Corfield, Alexandra Havdahl, Dinka Smajlagic, Ragnhild Eek Brandlistuen, Mari Vaage Wang, Laurel Fish, Marialivia Bernardi, Jessica van de Grint‐Stoop, Mona Bekkhus, Pasco Fearon   +10 more
wiley   +1 more source

Elevated Neutrophil Count as a Causal Risk Factor for Endometriosis: A Mendelian Randomization Study. [PDF]

Int J Womens Health
Li M, Zhou X, Chen Y.
europepmc   +1 more source

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
MR identified phenylalanine as a causal PC risk factor (OR 1.18). A 5‐gene RF model (AUC 0.955) highlighted SLC6A14 as the top biomarker. Single‐cell analysis revealed epithelial–immune crosstalk. Molecular docking identified genistein (−9.1 kcal/mol) as a lead SLC6A14‐targeting compound.
Xing Liu, Yibin Li, Fangfang Qin, Jianghong Ou   +3 more
wiley   +1 more source

Mendelian randomization analysis of the causal relationship between allergic rhinitis and depression and underlying mediation mechanisms. [PDF]

World Allergy Organ J
Zhang S, Wang R, Weng J, Li M, Shi M, Wei J, Ye L, Huang X, Huang W, Qu S.   +9 more
europepmc   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

From paradox to biology: shared genetic architecture underlies the inverse association between smoking and Sjögren's disease. [PDF]

Rheumatology (Oxford)
van der Merwe S, Zuckerman B, Liu W, Cheng W, Zhao SS.   +4 more
europepmc   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Alzheimer disease and lichen planus: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Huang W, Xiao L.
europepmc   +1 more source