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Genetic Correlation, Pleiotropy, and Molar Morphology in a Longitudinal Sample of Australian Twins and Families [PDF]
Genes, 2022 This study aims to expand our understanding of the genetic architecture of crown morphology in the human diphyodont dentition. Here, we present bivariate genetic correlation estimates for deciduous and permanent molar traits and evaluate the patterns of ...
Toby Hughes +2 more
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Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders
Biological Psychiatry, 2021 Genome-wide analyses of common and rare genetic variations have documented the heritability of major psychiatric disorders, established their highly polygenic genetic architecture, and identified hundreds of contributing variants. In recent years, these studies have illuminated another key feature of the genetic basis of psychiatric disorders: the ...
Jordan W Smoller +2 more
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Dissecting genetic correlation and pleiotropy through a genetic cross
2023Abstract Genetic correlation represents an important class of evolutionary constraint, which is itself evolvable. Empirical studies have found mixed results on whether genetic correlations change rapidly or slowly. This uncertainty challenges our ability to predict the outcome of selection.
Haoran Cai +2 more
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Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes [PDF]
Hypertension, 2014 Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component.
Verena Zuber +2 more
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Genetic Pleiotropies of Obesity
2013Advances in the knowledge of variation in the human genome and reproducible results from the Genome-wide Association Studies (GWAS) have led to the identification of susceptible loci contributing to obesity and related disorders. Obesity is associated with and may contribute to the development of many metabolic diseases including, but not limited to ...
Bratati Kahali, Elizabeth K. Speliotes
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The genetic architecture of domestication in the chicken: effects of pleiotropy and linkage
Molecular Ecology, 2010AbstractThe extent of pleiotropy and epistasis in quantitative traits remains equivocal. In the case of pleiotropy, multiple quantitative trait loci are often taken to be pleiotropic if their confidence intervals overlap, without formal statistical tests being used to ascertain if these overlapping loci are statistically significantly pleiotropic ...
Karin Schutz
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Pleiotropy, epistasis and the genetic architecture of quantitative traits
Nature Reviews GeneticsPleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions between genetic polymorphisms affect the same trait) are fundamental aspects of the genetic architecture of quantitative traits.
Robert Anholt, Trudy Mackay
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Genetic Pleiotropy of Bone-Related Phenotypes: Insights from Osteoporosis
Current Osteoporosis Reports, 2020We summarize recent evidence on the shared genetics within and outside the musculoskeletal system (mostly related to bone density and osteoporosis).Osteoporosis is determined by an interplay between multiple genetic and environmental factors. Significant progress has been made regarding its genetic background revealing a number of robustly validated ...
David Karasik
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Asthma and endocrine disorders: Shared mechanisms and genetic pleiotropy
Molecular and Cellular Endocrinology, 2011Asthma is a common inflammatory disease for which the cause is not yet known. Studies of the epidemiology and natural history of childhood asthma into adulthood demonstrate a change in gender prevalence with age. Hormones and inflammation may interact in asthma pathogenesis and determine its course.
Riccardina, Tesse +2 more
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