Results 141 to 150 of about 942,879 (267)

Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa. [PDF]

BMC Plant Biol, 2022
Biswal AK, Alakonya AE, Mottaleb KA, Hearne SJ, Sonder K, Molnar TL, Jones AM, Pixley KV, Prasanna BM.   +8 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Integrating image-based phenotyping and QTL mapping to enhance genetic resistance and accelerate breeding for bacterial grain rot resistance in rice. [PDF]

Theor Appl Genet
Park JR, Lee G, Lee HS, Lee SY, Ha SK, Kang K, Jin M, Suh JP, Seo J, Choi YM, Lee BC, Park HS.   +11 more
europepmc   +1 more source

COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints. [PDF]

Immunol Cell Biol, 2021
Goodnow CC.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

In silico QTL mapping in an oil palm breeding program reveals a quantitative and complex genetic resistance to Ganoderma boninense. [PDF]

Mol Breed, 2021
Daval A, Pomiès V, le Squin S, Denis M, Riou V, Breton F, Nopariansyah, Bink M, Cochard B, Jacob F, Billotte N, Tisné S.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Immune cell-resolved transcriptomics provides insights into the basis for variations of fish genetic resistance to viral disease. [PDF]

BMC Biol
Clark TC, Thomas V, Taylor RS, Charles M, Laurent A, Schwartz-Cornil I, Collet B, Lallias D, Macqueen DJ, Martin SAM, Boudinot P.   +10 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Role of Genetic Resistance in Rice Disease Management. [PDF]

Int J Mol Sci
Danso Ofori A, Zheng T, Titriku JK, Appiah C, Xiang X, Kandhro AG, Ahmed MI, Zheng A.   +7 more
europepmc   +1 more source