Genetic Resistance of Bovines to Theileriosis. [PDF]
Animals (Basel), 2022 Valente D +3 more
europepmc +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Contribution of the TCRβ Repertoire to Marek's Disease Genetic Resistance in the Chicken. [PDF]
Viruses, 2023 Hearn CJ, Cheng HH.
europepmc +1 more source
Searching for wide spectrum resistance to begomovirus disease in tomato in Réunion Island [PDF]
, 2008 The emergence of Tomato yellow leaf curl virus (TYLCV) and other begomoviruses from past decades in many countries was demonstrated to be coupled with the invasion of biotype B of the whitefly Bemisia tabaci.
Dintinger, Jacques
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Hot pepper (Capsicum chinense, Jacq.) inheritance of reaction to powdery mildew
Scientia Agricola, 2006 The pepper species C. chinense has been considered one of the most important resistance sources to powdery mildew Capsicum spp. However, the inheritance in this species was unknown. The purpose of this work was to study its reaction inheritance.
Sally Ferreira Blat +3 more
doaj
Pyrethroid genetic resistance in the dengue vector (Aedes aegypti) in Posadas, Argentina. [PDF]
Front Public Health, 2023 Fay JV +9 more
europepmc +1 more source
Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]
, 2019 The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source