Results 191 to 200 of about 566,900 (297)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic Variability of Loci Affecting Meat Quality and Production in Nero Siciliano Pig Breed. [PDF]

Animals (Basel)
Tumino S, Carlentini M, Chessari G, Criscione A, Antoci A, Marletta D, Bordonaro S.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Genetic Variability of Present-Day Bulgarians Captures Ancient and Recent Ancestral Contributions. [PDF]

Am J Biol Anthropol
Sarno S, Piccini F, Abondio P, Cilli E, Kuyumdjian EM, Dimitrov NA, Dilov CD, De Fanti S, Ciani G, Gentilini D, Boattini A, Sazzini M, Pettener D, Luiselli D.   +13 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Cardiac Phenotypes in Fabry Disease: Genetic Variability and Clinical Severity Staging Correlation in a Reference Center Cohort. [PDF]

Genes (Basel)
Faro DC, Di Salvo S, Rodolico MS, Losi V, Capodanno D, Monte IP.   +5 more
europepmc   +1 more source

Genetic evaluation of rice restorer lines through variability, heritability and genetic advance analysis

, 2019
Shweta Tiwari, G. K. Koutu, Yogendra Singh, Madhya Vidyalaya, Pradesh, G K Koutu, Singh, Yogendra   +6 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Nutritional Efficiency of <i>Coffea canephora</i>: The Role of Genetic Variability and Nutrient Accumulation. [PDF]

Plants (Basel)
Silva CAD, Dalazen JR, Rodrigues WP, Rocha RB, Partelli FL.   +4 more
europepmc   +1 more source

Variability in phase transition and contribution of genetic variance to yield in wheat at high altitude.

, 2011
B. B. Bandyopadhyay
openalex   +1 more source