Results 241 to 250 of about 6,167,941 (317)
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin +15 morewiley +1 more sourceThe atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger +17 morewiley +1 more sourceA large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas +20 morewiley +1 more sourceGenetic studies of body mass index yield new insights for obesity biology
Nature, 2015 A. Locke, Bratati Kahali, S. Berndt, A. Justice, T. Pers, F. Day, Corey Powell, S. Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. Randall, T. Winkler, A. Wood, T. Workalemahu, J. Faul, Jennifer A. Smith, J. Zhao, Wei Zhao, Jin Chen, R. Fehrmann, Å. Hedman, J. Karjalainen, Ellen M. Schmidt, D. Absher, N. Amin, Denise Anderson, M. Beekman, J. Bolton, J. Bragg-Gresham, S. Buyske, A. Demirkan, Guohong Deng, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, A. Goel, Jian Gong, A. Jackson, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, M. Mangino, I. M. Leach, C. Medina-Gomez, S. Medland, M. Nalls, Cameron D. Palmer, D. Pasko, S. Pechlivanis, M. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. W. Laan, J. V. Setten, J. V. Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, Gillian M. Arscott, A. Attwood, S. Bandinelli, Amy Barrett, Isabelita N. Bas, C. Bellis, A. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L. Bonnycastle, Y. Böttcher, H. Boyd, M. Bruinenberg, I. H. Caspersen, Y. I. Chen, R. Clarke, E. W. Daw, A. Craen, G. Delgado, M. Dimitriou, A. Doney, N. Eklund, K. Estrada, Elodie Eury, L. Folkersen, Ross M. Fraser, M. Garcia, F. Geller, V. Giedraitis, B. Gigante, A. Go, A. Golay, A. Goodall, S. Gordon, Mathias Gorski, H. Grabe, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, C. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A. James, J. Jeff, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N. Lee, P. Lichtner, L. Lind, J. Lindström, K. S. Lo, S. Lobbens, R. Lorbeer, Yingchang Lu, F. Mach, P. Magnusson, A. Mahajan, W. McArdle, S. McLachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K. Monda, M. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A. Musk, R. Nagaraja, M. Nöthen, I. Nolte, S. Pilz, N. W. Rayner, Frida Renstrom, R. Rettig, J. Ried, S. Ripke, N. Robertson, L. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, W. Scott, T. Seufferlein, Jianxin Shi, A. Smith, Joanna Smolonska, A. Stanton, V. Steinthorsdottir, K. Stirrups, H. Stringham, J. Sundström, M. Swertz, A. Swift, A. Syvänen, S. Tan, B. Tayo, B. Thorand, G. Thorleifsson, J. Tyrer, H. Uh, L. Vandenput, F. Verhulst, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, H. Warren, D. Waterworth, M. Weedon, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, E. Brennan, Murim Choi, Z. Dastani, A. Drong, P. Eriksson, A. Franco-Cereceda, J. Gådin, A. Gharavi, M. Goddard, R. Handsaker, Jinyan Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, Jong-Young Lee, L. Liang, R. Lifton, Baoshan Ma, S. Mccarroll, A. McKnight, J. Min, M. Moffatt, G. Montgomery, J. Murabito, G. Nicholson, D. Nyholt, Y. Okada, J. Perry, R. Dorajoo, E. Reinmaa, R. Salem, N. Sandholm, R. Scott, L. Stolk, A. Takahashi, Toshihiro Tanaka, F. V. Hooft, Anna A. E. Vinkhuyzen, H. Westra, W. Zheng, K. Zondervan, A. Heath, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, J. Blangero, P. Bovet, H. Campbell, M. Caulfield, G. Cesana, A. Chakravarti, D. Chasman, P. Chines, F. Collins, D. Crawford, L. Cupples, D. Cusi, J. Danesh, U. Faire, H. M. Ruijter, A. Dominiczak, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, S. Felix, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, O. Franco, R. Gansevoort, P. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A. Hall, T. Harris, A. Hattersley, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Homuth, G. K. Hovingh, S. Humphries, S. Hunt, E. Hyppönen, T. Illig, K. Jacobs, M. Jarvelin, K. Jöckel, B. Johansen, P. Jousilahti, J. Jukema, A. Jula, J. Kaprio, J. Kastelein, S. Keinanen-Kiukaanniemi, L. Kiemeney, P. Knekt, J. Kooner, C. Kooperberg, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, V. Lyssenko, S. Männistö, A. Marette, T. Matise, C. McKenzie, B. McKnight, F. Moll, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, P. Madden, G. Pasterkamp, J. Peden, A. Peters, D. Postma, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, P. Ridker, J. Rioux, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, H. Schunkert, P. Schwarz, P. Sever, A. Shuldiner, J. Sinisalo, R. Stolk, K. Strauch, A. Tönjes, D. Trégouët, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, U. Völker, G. Waeber, G. Willemsen, J. Witteman, M. Zillikens, L. Adair, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, S. Bornstein, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. D. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, J. Hui, D. Hunter, K. Hveem, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, A. Metspalu, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T. Saaristo, D. Saleheen, N. Sattar, E. Schadt, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, U. Thorsteinsdóttir, M. Stumvoll, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. Harst, M. Walker, H. Wallaschofski, N. Wareham, H. Watkins, D. Weir, H. Wichmann, James F. Wilson, P. Zanen, I. Borecki, P. Deloukas, C. Fox, I. Heid, J. O’Connell, D. Strachan, K. Stefánsson, C. Duijn, G. Abecasis, L. Franke, T. Frayling, M. McCarthy, P. Visscher, A. Scherag, C. Willer, M. Boehnke, K. Mohlke, C. Lindgren, J. Beckmann, I. Barroso, K. North, E. Ingelsson, J. Hirschhorn, R. Loos, Elizabeth K. Speliotes +481 moresemanticscholar +1 more sourceMultidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher +11 morewiley +1 more sourceGermline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog +5 morewiley +1 more source
