Results 11 to 20 of about 634,337 (325)
Frontiers in Neuroscience, 2021 Despite major advancements in gene therapy technologies, there are no approved gene therapies for diseases which predominantly effect the brain. Adeno-associated virus (AAV) vectors have emerged as the most effective delivery vector for gene therapy ...
Jonathan M. Fischell, Paul S. Fishman
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Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions
Viruses, 2021 Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak +5 more
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An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes
Biology Open, 2022 Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk +7 more
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Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us [PDF]
, 2013 Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification ...
Berry, Vincent +7 more
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Molecular Genetic Manipulation of Vector Mosquitoes [PDF]
Cell Host & Microbe, 2008 Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Terenius, Olle +3 more
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Prospects for transgenesis in the chick [PDF]
, 2004 Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman +52 more
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Pharmaceutics, 2022 Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma +4 more
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Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]
, 2011 Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
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A hierarchical genetic disparity estimation algorithm for multiview image synthesis [PDF]
, 2000 A hierarchical genetic algorithm for disparity estimation is presented. The goal, to estimate reliable disparity fields with low computational cost, is reached using a hierarchical genetic matching procedure.
Bull, DR +3 more
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Genetic elimination of dengue vector mosquitoes [PDF]
Proceedings of the National Academy of Sciences, 2011 An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Megan R, Wise de Valdez +6 more
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