Results 11 to 20 of about 617,752 (328)

Emerging Cancer Vaccines: The Promise of Genetic Vectors [PDF]

open access: yesCancers, 2011
Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication.
Gennaro Ciliberto, Luigi Aurisicchio
openaire   +3 more sources

Targeted therapy in age-related macular degeneration (AMD)

open access: yesJournal of Education, Health and Sport, 2020
Introduction and purpose: Age-related macular degeneration (AMD) is a major cause of blindness in highly developed countries, with blindness frequency of 8.7%.
Klaudia Daria Szumna   +4 more
doaj   +1 more source

Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions

open access: yesViruses, 2021
Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak   +5 more
doaj   +1 more source

Molecular Genetic Manipulation of Vector Mosquitoes [PDF]

open access: yesCell Host & Microbe, 2008
Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Olle Terenius   +3 more
openaire   +3 more sources

An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes

open access: yesBiology Open, 2022
Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk   +7 more
doaj   +1 more source

Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us [PDF]

open access: yes, 2013
Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification ...
Berry, Vincent   +7 more
core   +9 more sources

Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]

open access: yes, 2011
Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
core   +2 more sources

A Quality by Design Approach in Pharmaceutical Development of Non-Viral Vectors with a Focus on miRNA

open access: yesPharmaceutics, 2022
Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma   +4 more
doaj   +1 more source

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