Results 11 to 20 of about 123,260 (289)
Targeted therapy in age-related macular degeneration (AMD)
Journal of Education, Health and Sport, 2020 Introduction and purpose: Age-related macular degeneration (AMD) is a major cause of blindness in highly developed countries, with blindness frequency of 8.7%.
Klaudia Daria Szumna +4 more
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Genetics of Mosquito Vector Competence [PDF]
Microbiology and Molecular Biology Reviews, 2000 SUMMARY Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Efforts to control mosquito-borne diseases have been impeded, in part, by the development of drug-resistant parasites, insecticide-resistant mosquitoes, and environmental concerns over the application of ...
Brenda T. Beerntsen +2 more
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Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions
Viruses, 2021 Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak +5 more
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An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes
Biology Open, 2022 Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk +7 more
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Molecular Genetic Manipulation of Vector Mosquitoes [PDF]
Cell Host & Microbe, 2008 Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Olle Terenius +3 more
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Pharmaceutics, 2022 Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma +4 more
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Frontiers in Cellular and Infection Microbiology, 2021 The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias +5 more
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Simple Genetic Operators are Universal Approximators of Probability Distributions (and other Advantages of Expressive Encodings) [PDF]
, 2022 This paper characterizes the inherent power of evolutionary algorithms. This power depends on the computational properties of the genetic encoding. With some encodings, two parents recombined with a simple crossover operator can sample from an arbitrary distribution of child phenotypes.
arxiv +1 more source
Genetic elimination of dengue vector mosquitoes [PDF]
Proceedings of the National Academy of Sciences, 2011 An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Hong-Fei Gong +6 more
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Biological Procedures Online, 2003 Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C. +3 more
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