Results 31 to 40 of about 4,784,986 (369)
Human Vaccines & Immunotherapeutics, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler +12 more
doaj +1 more source
Sparse reduced-rank regression for imaging genetics studies: models and applications [PDF]
, 2012 We present a novel statistical technique; the sparse reduced rank regression (sRRR) model which is a strategy for multivariate modelling of high-dimensional imaging responses and genetic predictors.
Vounou, Maria, Vounou, Maria
core +1 more source
Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]
, 2014 Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R +3 more
core +1 more source
Recent advances in genetic modification of adenovirus vectors for cancer treatment
Cancer Science, 2017 Adenoviruses are widely used to deliver genes to a variety of cell types and have been used in a number of clinical trials for gene therapy and oncolytic virotherapy. However, several concerns must be addressed for the clinical use of adenovirus vectors.
Yuki Yamamoto +3 more
semanticscholar +1 more source
Insight into the Machinery and Applications for Understanding the Pathogen- Vector Interface [PDF]
, 2012 The availability of genome sequencing data in combination with knowledge of expressed genes via transcriptome and proteome data has greatly advanced our understanding of arthropod vectors of disease.
Barnard, Annette-Christi +4 more
core +1 more source
Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]
PLoS ONE, 2017 Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch +10 more
doaj +1 more source
Онкогематология, 2022 By present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can ...
S. E. Ipatov, S. A. Roumiantsev
doaj
Biological Procedures Online, 2003 Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C. +3 more
doaj +1 more source
RNA Viral Vectors for Accelerating Plant Synthetic Biology
Frontiers in Plant Science, 2021 The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar +3 more
doaj +1 more source
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]
PLoS ONE, 2012 In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen +6 more
doaj +1 more source