Sparse reduced-rank regression for imaging genetics studies: models and applications [PDF]
, 2012 We present a novel statistical technique; the sparse reduced rank regression (sRRR) model which is a strategy for multivariate modelling of high-dimensional imaging responses and genetic predictors.
Vounou, Maria, Vounou, Maria
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Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]
PLoS ONE, 2012 In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen +6 more
doaj +1 more source
The genetic basis of host preference and resting behavior in the major African malaria vector, Anopheles arabiensis [PDF]
, 2016 Malaria transmission is dependent on the propensity of Anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. Recent increases in the usage of Long Lasting Insecticide Treated Nets (LLINs) in Africa have been associated ...
Collier, T. J. +12 more
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BiomedicinesBackground: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov +11 more
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Онкогематология, 2022 By present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can ...
S. E. Ipatov, S. A. Roumiantsev
doaj
Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium [PDF]
, 2015 © 2015 Webster et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in ...
A. A. Hamidou +23 more
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Genetic modification of baculovirus expression vectors
Virologica Sinica, 2012 As a protein expression vector, the baculovirus demonstrates many advantages over other vectors. With the development of biotechnology, baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.
Shu-fen, Li +3 more
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Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Biomedicines, 2013 Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso +2 more
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Genetic Variation in Insect Vectors: Death of Typology?
Insects, 2018 The issue of typological versus population thinking in biology is briefly introduced and defined. It is then emphasized how population thinking is most relevant and useful in vector biology.
Jeffrey R. Powell
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Colony polymerase chain reaction of stably transfected Trypanosoma cruzi grown on solid medium [PDF]
Memorias do Instituto Oswaldo Cruz, 2000 Tools for the genetic manipulation of Trypanosoma cruzi are largely unavailable, although several vectors for transfection of epimastigotes and expression of foreign or recombinant genes have been developed. We have previously constructed several plasmid
Wagner G dos Santos +2 more
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