Results 31 to 40 of about 617,752 (328)
Biological Procedures Online, 2003 Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C. +3 more
doaj +1 more source
RNA Viral Vectors for Accelerating Plant Synthetic Biology
Frontiers in Plant Science, 2021 The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar +3 more
doaj +1 more source
Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. [PDF]
, 2013 An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation.
Easlon, Hsien M +9 more
core +1 more source
Онкогематология, 2022 By present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can ...
S. E. Ipatov, S. A. Roumiantsev
doaj
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]
PLoS ONE, 2012 In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen +6 more
doaj +1 more source
A method for generating realistic correlation matrices [PDF]
, 2013 Simulating sample correlation matrices is important in many areas of statistics. Approaches such as generating Gaussian data and finding their sample correlation matrix or generating random uniform $[-1,1]$ deviates as pairwise correlations both have ...
Garcia, Stephan Ramon +2 more
core +5 more sources
Strategies for Assessing Arbovirus Genetic Variability in Vectors and/or Mammals [PDF]
Pathogens, 2020 Animal arboviruses replicate in their invertebrate vectors and vertebrate hosts. They use several strategies to ensure replication/transmission. Their high mutation rates and propensity to generate recombinants and/or genome segment reassortments help them adapt to new hosts/emerge in new geographical areas.
Migné, Camille +2 more
openaire +5 more sources
BiomedicinesBackground: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov +11 more
doaj +1 more source
Perinatal Gene Transfer to the Liver [PDF]
, 2011 The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM +6 more
core +1 more source
Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Biomedicines, 2013 Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso +2 more
doaj +1 more source