Genetically modified mouse models to help fight COVID-19. [PDF]
Nat Protoc, 2020 The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19).
Gurumurthy CB +5 more
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Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models [PDF]
Frontiers in Neuroscience, 2013 Ghrelin is an octanoylated peptide hormone, produced by endocrine cells of the stomach, which acts in the brain to increase food intake and body weight.
Aki eUchida +2 more
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Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation. [PDF]
PLoS ONE, 2008 Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background.Reported here is the development of an easily implemented method that consistently yields ...
G Charles Ostermeier +3 more
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Genetically Modified Mouse Models of Congenital Diaphragmatic Hernia: Opportunities and Limitations for Studying Altered Lung Development. [PDF]
Front Pediatr, 2022 Congenital diaphragmatic hernia (CDH) is a relatively common and life-threatening birth defect, characterized by an abnormal opening in the primordial diaphragm that interferes with normal lung development. As a result, CDH is accompanied by immature and
Friedmacher F, Rolle U, Puri P.
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Ocular surface mucins and local inflammation--studies in genetically modified mouse lines. [PDF]
BMC Ophthalmol, 2015 Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e.
Shirai K, Saika S.
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Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B. [PDF]
Mol Autism, 2020 Background Partial or an entire deletion of SHANK3 are considered as major drivers in the Phelan–McDermid syndrome, in which 75% of patients are diagnosed with autism spectrum disorder (ASD).
Perets N +4 more
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Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models [PDF]
Cells, 2021 Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic ...
Verónica A. García-García +3 more
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Protocol for live imaging of bacteria-cell interactions in genetically modified mouse small intestinal organoids [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol for microinjection of bacteria into mouse small intestinal organoids that recapitulates the natural route of infection of intestinal epithelial cells from the intestinal lumen.
Minhee Kim +4 more
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Genetically modified mouse models for the study of nonalcoholic fatty liver disease. [PDF]
World J Gastroenterol, 2012 Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (1) fatty liver (hepatic steatosis); (2) steatosis with inflammation and necrosis; to
Nagarajan P +4 more
europepmc +4 more sources
Probing the Scope and Mechanisms of Calcitriol Actions Using Genetically Modified Mouse Models [PDF]
JBMR Plus, 2021 Genetically modified mice have provided novel insights into the mechanisms of activation and inactivation of vitamin D, and in the process have provided phenocopies of acquired human disease such as rickets and osteomalacia and inherited diseases such as
Dengshun Miao, David Goltzman
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