Genetically modified mouse models to help fight COVID-19. [PDF]
Nat Protoc, 2020 The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19).
Gurumurthy CB +5 more
europepmc +6 more sources
Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models [PDF]
Frontiers in Neuroscience, 2013 Ghrelin is an octanoylated peptide hormone, produced by endocrine cells of the stomach, which acts in the brain to increase food intake and body weight.
Aki eUchida +2 more
doaj +5 more sources
Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation. [PDF]
PLoS ONE, 2008 Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background.Reported here is the development of an easily implemented method that consistently yields ...
G Charles Ostermeier +3 more
doaj +6 more sources
Genetically Modified Mouse Models of Congenital Diaphragmatic Hernia: Opportunities and Limitations for Studying Altered Lung Development. [PDF]
Front Pediatr, 2022 Congenital diaphragmatic hernia (CDH) is a relatively common and life-threatening birth defect, characterized by an abnormal opening in the primordial diaphragm that interferes with normal lung development. As a result, CDH is accompanied by immature and
Friedmacher F, Rolle U, Puri P.
europepmc +4 more sources
Ocular surface mucins and local inflammation--studies in genetically modified mouse lines. [PDF]
BMC Ophthalmol, 2015 Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e.
Shirai K, Saika S.
europepmc +4 more sources
Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B. [PDF]
Mol Autism, 2020 Background Partial or an entire deletion of SHANK3 are considered as major drivers in the Phelan–McDermid syndrome, in which 75% of patients are diagnosed with autism spectrum disorder (ASD).
Perets N +4 more
europepmc +4 more sources
Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models [PDF]
Cells, 2021 Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic ...
Verónica A. García-García +3 more
doaj +3 more sources
Genetically modified mouse models to study hepatic neutral lipid mobilization. [PDF]
Biochim Biophys Acta Mol Basis Dis, 2019 Excessive accumulation of triacylglycerol is the common denominator of a wide range of clinical pathologies of liver diseases, termed non-alcoholic fatty liver disease. Such excessive triacylglycerol deposition in the liver is also referred to as hepatic steatosis.
Haemmerle G, Lass A.
europepmc +4 more sources
Protocol for live imaging of bacteria-cell interactions in genetically modified mouse small intestinal organoids [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol for microinjection of bacteria into mouse small intestinal organoids that recapitulates the natural route of infection of intestinal epithelial cells from the intestinal lumen.
Minhee Kim +4 more
doaj +3 more sources
Genetically Modified Mouse Models in Studies on Cutaneous Wound Healing [PDF]
Experimental Physiology, 2000 Genetically modified mice have become an invaluable tool in modern biomedical and basic research. This review provides an overview of knockout and transgenic mice studied with regard to their cutaneous wound healing properties. In addition, several gene transfer studies are briefly introduced, which have further highlighted our knowledge on individual ...
Annette Scheid +3 more
semanticscholar +6 more sources