Results 31 to 40 of about 390,635 (308)

Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance Our current understanding of genetic disease is often inadequate, largely due to genetic background effects that modify disease presentation. This is particularly challenging for rare diseases that lack sufficient numbers of patients for genome-wide association studies.
Ramsbottom, Simon, Thelwall, Peter, Wood, Katrina, Clowry, Gavin, Devlin, Laura, Silbermann, Flora, Spiewak, Helena, Shril, Shirlee, Molinari, Elisa, Hildebrandt, Friedhelm, Gunay-Aygun, Meral, Saunier, Sophie, Cordell, Heather, Sayer, John, Miles, Colin   +14 more
openaire   +4 more sources

The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community

G3: Genes, Genomes, Genetics, 2020
The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the
Estelle Wall, Jonathan Scoles, Adriane Joo, Ophir Klein, Carlo Quinonez, Jeffrey O. Bush, Gail R. Martin, Diana J. Laird   +7 more
doaj   +1 more source

Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery

Nature Communications, 2020
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be used
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca   +23 more
doaj   +1 more source

Genetically modified mice for research on human diseases: A triumph for Biotechnology or a work in progress?

The EuroBiotech Journal, 2022
Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice.
Brown Richard E.
doaj   +1 more source

Of Mice and Molecules: Research with Genetically Modified Mouse Models

Environmental Health Perspectives, 2005
Sara Shostak
openalex   +2 more sources

QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment

OncoImmunology, 2022
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties.
Kaspar Bresser, Meike E. W. Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J. Kroese, Ton N. Schumacher   +8 more
doaj   +1 more source

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

STAR Protocols, 2022
Summary: We have previously developed 3D tumoroids derived from genetically engineered mouse models (GEMMs) of BRCA1/2-deficient breast cancer. Here, we describe how to genetically modify tumoroids, use them for functional genetic dropout screens, and ...
Mariana Paes Dias, Sven Rottenberg, Jos Jonkers   +2 more
doaj   +1 more source

A Simple and Fast Battery Test for Phenotypic Characterization of Mice

Bio-Protocol, 2020
Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters.
Mariana Garcia-Gomes , Dennis Zanatto, Pedro Yamamoto, Danilo Wadt, Ana Antiorio, Jilma Aleman-Laporte, Sandra Alexandre-Ribeiro, Guilherme Marson, Cezar Guizzo, Silvia Massironi, Maria Bernardi, Claudia Mori   +11 more
doaj   +1 more source

The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth

Cells, 2021
In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master
Sarmed Al-Samerria, Sally Radovick
doaj   +1 more source

Simultaneous detection of multiple transgenes for genetically-modified mouse strains.

Experimental Animals, 2009
Recent advances in the genetic manipulation of mice have enabled us to generate transgenic and knockout mice. However, it is not easy to maintain these genetically-modified mice with the high-quality necessary to meet both scientific and legal requirements. RIKEN BRC has collected various transgenic, knockout, and conditional knockout mice.
Hatsumi Nakata, Tomomi Hashimoto, Y. Seki, K. Mekada, Y. Obata, A. Yoshiki   +5 more
semanticscholar   +4 more sources