Results 31 to 40 of about 522,034 (344)
Frontiers in Veterinary Science, 2023 Gene editing tools have become an indispensable part of research into the fundamental aspects of cell biology. With a vast body of literature having been generated based on next generation sequencing technologies, keeping track of this ever-growing body ...
Ali Mazloum +7 more
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Of Mice and Molecules: Research with Genetically Modified Mouse Models
Environmental Health Perspectives, 2005 Sara Shostak
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Generation of an immortalized mouse embryonic palatal mesenchyme cell line. [PDF]
PLoS ONE, 2017 Palatogenesis is a complex morphogenetic process, disruptions in which result in highly prevalent birth defects in humans. In recent decades, the use of model systems such as genetically-modified mice, mouse palatal organ cultures and primary mouse ...
Katherine A Fantauzzo, Philippe Soriano
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Animal models for COVID-19: advances, gaps and perspectives
Signal Transduction and Targeted Therapy, 2022 COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy, as well as ...
Changfa Fan +7 more
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Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Our current understanding of genetic disease is often inadequate, largely due to genetic background effects that modify disease presentation. This is particularly challenging for rare diseases that lack sufficient numbers of patients for genome-wide association studies.
Ramsbottom, Simon +14 more
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CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]
, 2020 The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I +2 more
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G3: Genes, Genomes, Genetics, 2020 The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the
Estelle Wall +7 more
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Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
Nature Communications, 2020 CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be used
Anders Lundin +23 more
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The EuroBiotech Journal, 2022 Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice.
Brown Richard E.
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OncoImmunology, 2022 The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties.
Kaspar Bresser +8 more
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