Results 31 to 40 of about 140,816 (272)
Cells, 2021 In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master
Sarmed Al-Samerria, Sally Radovick
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A Simple and Fast Battery Test for Phenotypic Characterization of Mice
Bio-Protocol, 2020 Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters.
Mariana Garcia-Gomes +11 more
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DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE
Фармация и фармакология (Пятигорск), 2023 α-synuclein is one of the key molecular links in the pathogenesis of Parkinson’s disease. The accumulated data indicate that pathogenic mutations in the Snca gene are associated with the development of neurodegenerative brain damage, indicating the ...
E. A. Patrakhanov +8 more
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Frontiers in Bioengineering and Biotechnology, 2021 There continues to be an erroneous belief that allergens (especially food allergens) are more resistant to gastrointestinal digestion than non-allergens.
Rod A. Herman, Jason M. Roper
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BMC Genomics, 2022 Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics.
Jonathan W. Villanueva +8 more
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The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models
Frontiers in Oncology, 2014 PTEN negatively regulates PI3K signalling by dephosphorylating PIP3 to PIP2. AKT is activated downstream of PIP3 to mediate physiologic processes. Furthermore, substantial crosstalk exists with other signalling networks at all levels of the PI3K pathway.
Amancio eCarnero +2 more
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
Nature Communications, 2020 The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to ...
Andrea Walens +15 more
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Establishment of hKDR+/+ Humanized and Rag1-/- Gene Knockout Double Genetically Modified Mouse Model
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveThrough improving the potential of vascular endothelial growth factor receptor (VEGFR)-humanized mouse model (hKDR+/+) with C57BL/6N background to allow the growth of different mouse tumor cell lines, to establish novel tumor-bearing mouse ...
LIU Susu +7 more
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F1000Research, 2013 Background: The pore-forming subunit of the cardiac sodium channel, Nav1.5, has been previously found to be mutated in genetically determined arrhythmias. Nav1.5 associates with many proteins that regulate its function and cellular localisation. In order
Katja Reinhard +3 more
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Genetically modified mouse models addressing gonadotropin function
Reproductive Biology, 2014 The development of genetically modified animals has been useful to understand the mechanisms involved in the regulation of the gonadotropin function. It is well known that alterations in the secretion of a single hormone is capable of producing profound reproductive abnormalities.
Laura D. Ratner +2 more
openaire +3 more sources