Establishment of hKDR+/+ Humanized and Rag1-/- Gene Knockout Double Genetically Modified Mouse Model
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveThrough improving the potential of vascular endothelial growth factor receptor (VEGFR)-humanized mouse model (hKDR+/+) with C57BL/6N background to allow the growth of different mouse tumor cell lines, to establish novel tumor-bearing mouse ...
LIU Susu +7 more
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First study on iron complexes in blood and organ samples from thalassaemic and normal laboratory mice using Moessbauer spectroscopy [PDF]
European Biophysics Journal Volume 47, Issue 2, 1 March 2018,
Pages 131-138, 2018 In this paper, blood and tissues samples from one normal and one thalassaemic lab-mice were studied using 57Fe Mossbauer spectroscopy at 78K for the first time. In contrast to human patients, these laboratory mice did not receive any medical treatment, thus the iron components present in the samples are not altered.
arxiv +1 more source
Genetically modified mouse models addressing gonadotropin function
Reproductive Biology, 2014 The development of genetically modified animals has been useful to understand the mechanisms involved in the regulation of the gonadotropin function. It is well known that alterations in the secretion of a single hormone is capable of producing profound reproductive abnormalities.
Laura D. Ratner +2 more
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SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements [PDF]
BMC Genetics 2007 8:78, 2008 Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new transcript. Several examples in the literature show that isoforms generated by an exonization are specific to a certain ...
arxiv +1 more source
Manipulations with early mouse embryos for generation of genetically modified animals
Вавиловский журнал генетики и селекции, 2017 Recently, genome-editing technologies have become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev +2 more
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An open-source video tracking system for mouse locomotor activity analysis
BMC Research Notes, 2020 Objective The ability to accurately and efficiently quantify mouse locomotor activity is essential for evaluating therapeutic efficacy and phenotyping genetically modified mice, in particular for the research of neuromuscular diseases.
Chen Zhang, Haiwen Li, Renzhi Han
doaj +1 more source
Genetic platelet depletion is superior in platelet transfusion compared to current models
Haematologica, 2020 Genetically modified mice have advanced our knowledge on platelets in hemostasis and beyond tremendously. However, mouse models harbor certain limitations, including availability of platelet specific transgenic strains, and off-target effects on other ...
Manuel Salzmann +11 more
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Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation
Frontiers in Genome Editing, 2023 Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models.
Daniel J. Davis +6 more
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Mapping genetic modifiers of survival in a mouse model of Dravet syndrome [PDF]
Genes, Brain and Behavior, 2013 Epilepsy is a common neurological disorder affecting approximately 1% of the population. Mutations in voltage‐gated sodium channels are responsible for several monogenic epilepsy syndromes. More than 800 mutations in the voltage‐gated sodium channel SCN1A have been reported in patients with generalized epilepsy with febrile seizures plus and Dravet ...
Jennifer A. Kearney +3 more
openaire +3 more sources
Cancer immunoprevention: from mice to early clinical trials
BMC Immunology, 2018 Cancer immunoprevention is based on the fact that a functioning immune system controls tumor onset and development in humans and animals, thus leading to the idea that the enhancement of immune responses in healthy individuals could effectively reduce ...
Arianna Palladini +3 more
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