Results 41 to 50 of about 277,970 (322)
F1000Research, 2013 Background: The pore-forming subunit of the cardiac sodium channel, Nav1.5, has been previously found to be mutated in genetically determined arrhythmias. Nav1.5 associates with many proteins that regulate its function and cellular localisation. In order
Katja Reinhard +3 more
doaj +1 more source
BMC Genomics, 2022 Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics.
Jonathan W. Villanueva +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 There continues to be an erroneous belief that allergens (especially food allergens) are more resistant to gastrointestinal digestion than non-allergens.
Rod A. Herman, Jason M. Roper
doaj +1 more source
Development of an ex vivo model for the study of cerebrovascular function utilizing isolated mouse olfactory artery [PDF]
, 2015 OBJECTIVE: Cerebral vessels, such as intracerebral perforating arterioles isolated from rat brain, have been widely used as an ex vivo model to study the cerebrovascular function associated with cerebrovascular disorders and the therapeutic effects of ...
Dietrich, Hans H. +3 more
core +2 more sources
The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models
Frontiers in Oncology, 2014 PTEN negatively regulates PI3K signalling by dephosphorylating PIP3 to PIP2. AKT is activated downstream of PIP3 to mediate physiologic processes. Furthermore, substantial crosstalk exists with other signalling networks at all levels of the PI3K pathway.
Amancio eCarnero +2 more
doaj +1 more source
Prospects for transgenesis in the chick [PDF]
, 2004 Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman +52 more
core +1 more source
Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
Nature Communications, 2020 The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to ...
Andrea Walens +15 more
doaj +1 more source
Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]
, 2014 Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin +9 more
core +2 more sources
Genetic‐Genomic Replication to Identify Candidate Mouse Atherosclerosis Modifier Genes [PDF]
Journal of the American Heart Association, 2013 Objective Genetics plays a large role in atherosclerosis susceptibility in humans and mice. We attempted to confirm previously determined mouse atherosclerosis‐associated loci and use bioinformatics and transcriptomics to create a catalog of candidate atherosclerosis modifier genes at these loci.
Hsu, Jeffrey, Smith, Jonathan D.
openaire +2 more sources
Manipulations with early mouse embryos for generation of genetically modified animals
Вавиловский журнал генетики и селекции, 2017 Recently, genome-editing technologies have become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev +2 more
doaj +1 more source