Results 41 to 50 of about 390,635 (308)
DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE
Фармация и фармакология (Пятигорск), 2023 α-synuclein is one of the key molecular links in the pathogenesis of Parkinson’s disease. The accumulated data indicate that pathogenic mutations in the Snca gene are associated with the development of neurodegenerative brain damage, indicating the ...
E. A. Patrakhanov +8 more
doaj +1 more source
Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy
Biochemistry and Biophysics Reports, 2016 Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice bearing the same ATTRV30M transgene. Amyloid deposition, transthyretin
Elena Panayiotou +7 more
openalex +3 more sources
F1000Research, 2013 Background: The pore-forming subunit of the cardiac sodium channel, Nav1.5, has been previously found to be mutated in genetically determined arrhythmias. Nav1.5 associates with many proteins that regulate its function and cellular localisation. In order
Katja Reinhard +3 more
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BMC Genomics, 2022 Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics.
Jonathan W. Villanueva +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 There continues to be an erroneous belief that allergens (especially food allergens) are more resistant to gastrointestinal digestion than non-allergens.
Rod A. Herman, Jason M. Roper
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Genetically modified mouse models in studies of luteinising hormone action
Molecular and Cellular Endocrinology, 2006 Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH ...
I. Huhtaniemi +5 more
semanticscholar +4 more sources
The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models
Frontiers in Oncology, 2014 PTEN negatively regulates PI3K signalling by dephosphorylating PIP3 to PIP2. AKT is activated downstream of PIP3 to mediate physiologic processes. Furthermore, substantial crosstalk exists with other signalling networks at all levels of the PI3K pathway.
Amancio eCarnero +2 more
doaj +1 more source
Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
Nature Communications, 2020 The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to ...
Andrea Walens +15 more
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Genetic‐Genomic Replication to Identify Candidate Mouse Atherosclerosis Modifier Genes [PDF]
Journal of the American Heart Association, 2013 Objective Genetics plays a large role in atherosclerosis susceptibility in humans and mice. We attempted to confirm previously determined mouse atherosclerosis‐associated loci and use bioinformatics and transcriptomics to create a catalog of candidate atherosclerosis modifier genes at these loci.
Hsu, Jeffrey, Smith, Jonathan D.
openaire +2 more sources
Establishment of hKDR+/+ Humanized and Rag1-/- Gene Knockout Double Genetically Modified Mouse Model
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveThrough improving the potential of vascular endothelial growth factor receptor (VEGFR)-humanized mouse model (hKDR+/+) with C57BL/6N background to allow the growth of different mouse tumor cell lines, to establish novel tumor-bearing mouse ...
LIU Susu +7 more
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