Results 71 to 80 of about 169,763 (304)

Techniques for RNA in vivo imaging in plants [PDF]

, 2014
Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A framework for a European network for a systematic environmental impact assessment of genetically modified organisms (GMO) [PDF]

, 2012
The assessment of the impacts of growing genetically modified (GM) crops remains a major political and scientific challenge in Europe. Concerns have been raised by the evidence of adverse and unexpected environmental effects and differing opinions on the
Andersen, Erling, Aslaksen, Iulie, Bernard, Jeannette, Binimelis, Rosa, Bohn, Thomas, Breckling, Boder, Buiatti, Marcello, Catacora-Vargas, Georgina, Dalgaard, Tommy, Darvas, Béla, Debeljak, Marko, Dudel, Gert, Dzeroski, Saso, Giovannetti, Manuela, Graef, Frieder, Henle, Klaus, Hilbeck, Angelika, Knäbe, Silvio, Maly, Stanislav, Metzger, Marc J., Meyer, Hartmut, Murphy-Bokern, Donal, Myhr, Anne Ingeborg, Oehen, Bernadette, Paetz, Andreas, Pesch, Roland, Quist, David, Römbke, Jörg, Settele, Josef, Stachow, Ulrich, Székács, András, Séralini, Gilles-Eric, Tappeser, Beatrix, van Gestel, Cornelis A.M., Werner, Armin, Wosniok, Werner, Wurbs, Angelika, Wynne, Brian   +37 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Deliberate release of genetically modified plants into the environment in Slovenia

Acta Agriculturae Slovenica, 2015
Deliberate release of genetically modified higher plants (GMHPs) into the environment in Slovenia is regulated by the Law on the Management of Genetically Modified Organisms (ZRGSO) Ur. l. RS 23/2005 and 21/2010, III chapter.
Zlata LUTHAR
doaj   +1 more source

Applicability of the EFSA Opinion on site‐directed nucleases type 3 for the safety assessment of plants developed using site‐directed nucleases type 1 and 2 and oligonucleotide‐directed mutagenesis

EFSA Journal, 2020
The European Commission requested the EFSA Panel on Genetically Modified Organisms (GMO) to assess whether section 4 (hazard identification) and the conclusions of EFSA's Scientific opinion on the risk assessment of plants developed using zinc finger ...
EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel), Hanspeter Naegeli, Jean‐Louis Bresson, Tamas Dalmay, Ian Crawford Dewhurst, Michelle M Epstein, Leslie George Firbank, Philippe Guerche, Jan Hejatko, Francisco Javier Moreno, Ewen Mullins, Fabien Nogué, Jose Juan Sánchez Serrano, Giovanni Savoini, Eve Veromann, Fabio Veronesi, Josep Casacuberta, Andrea Gennaro, Konstantinos Paraskevopoulos, Tommaso Raffaello, Nils Rostoks   +20 more
doaj   +1 more source

Organic farming and gene transfer from genetically modified crops [PDF]

, 1999
This is the final report of MAFF/Defra project OF0157. Genetically modified (GM) crops cannot be released into the environment and used as food, feed, medicines or industrial processing before they have passed through a rigorous and internationally ...
Dale, Philip J., Moyes, Catherine L.
core  

Evaluation of the risks of contaminating low erucic acid rapeseed with high erucic rapeseed and identification of mitigation strategies [PDF]

, 2019
High erucic acid rapeseed (HEAR) oil is under increasing demand for various industrial applications. However, many growers are concerned that if they grow the crop, they will not be able to revert to other rapeseed varieties in the future due to the risk
Bennett, Bilsborrow, Brookes, Carter, Downey, Eastern, Friedt, Henry, Ingram, Kightley, Knutsen, Kramer, Lutman, Messéan, Moyes, Norris, Robson, Sovero, Squire, Squire, Sweet, Söchting, Zanettti   +22 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source