Results 1 to 10 of about 1,347,877 (321)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Landscape genetics and gene flow in the banana pathogenic fungus Mycosphaerella fijiensis [PDF]

, 2007
Among the different evolutionary forces driving population genetics, gene flow related to dispersal plays a major role in local adaptation processes. However very few studies on plant pathogenic fungi focussed on deciphering gene flow patterns at the ...
Carlier, Jean, Cogneau-Perineau, Sonia, De Lapeyre de Bellaire, Luc, Halkett, Fabien, Pignolet, Luc, Ravigné, Virginie, Rieux, Adrien, Zapater, Marie-Françoise   +7 more
core  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Using neutral cline decay to estimate contemporary dispersal: a generic tool and its application to a major crop pathogen [PDF]

, 2013
Dispersal is a key parameter of adaptation, invasion and persistence. Yet standard population genetics inference methods hardly distinguish it from drift and many species cannot be studied by direct mark-recapture methods.
Amil, Barton, Barton, Barton, Barton, Barton, Broquet, Brown, Burt, Carlier, Chen, Daguin, Dieckmann, Endler, Fisher, Gay, Giraud, Goudet, Guillot, Guillot, Halkett, Jones, Lapeyre de Bellaire, Lebreton, Lenormand, Lenormand, Lenormand, Lenormand, Lockwood, McCartney, McDonald, Mourichon, Neu, Pennisi, Rieux, Rieux, Robert, Ronce, Rousset, Rousset, Rousset, Saccheri, Sackett, Slatkin, Storey, Turelli, Zapater   +46 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The contribution of statistical physics to evolutionary biology

, 2011
Evolutionary biology shares many concepts with statistical physics: both deal with populations, whether of molecules or organisms, and both seek to simplify evolution in very many dimensions.
Ao, Baake, Baake, Bak, Barton, Barton, Barton, Barton, Barton, Barton, Bauer, Beaumont, Boltzmann, Bürger, Callen, Crow, Davis, de Vladar, Demetrius, Demetrius, Derrida, Eigen, Elena, Ewens, Ewens, Fisher, Fisher, Fisher, Fisher, Frank, Frieden, Galtier, Gavrilets, Geyer, Haldane, Haldane, Hallatschek, Hallatschek, Hallatschek, Hamilton, Harold P. de Vladar, Hastings, Hermisson, Iwasa, Judson, Kauffman, Kimura, Kimura, Kimura, Kimura, Kimura, Kolmogorov, Kolmogorov, Kolmogorov, Korolev, Lande, Lande, Leibler, Livnat, Luria, Lynch, Mackay, Maynard-Smith, Maynard-Smith, Metropolis, Mustonen, Neher, Nicholas H. Barton, Peck, Peck, Penna, Price, Prügel-Bennett, Ralph, Rattray, Rouhani, Rouzine, Rouzine, Schrödinger, Sella, Shannon, Sneppen, Szymura, Taylor, Timofeéff-Ressovsky, Watkins, Wilke, Worden, Wright, Wright, Wright, Wright   +91 more
core   +1 more source

Wright-fisher-like models with constant population size on average [PDF]

, 2017
We first recall some basic facts from the theory of discrete-time Markov chains arising from two types neutral and non-neutral evolution models of population genetics with constant size.
Grosjean, Nicolas, Huillet, Thierry
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Genetics of an Isolated Population of Plethodon hubrichti [PDF]

, 2019
Undergraduate ...
de Araujo, Olivia, Plitt, Victoria, Thorpe, Whitney   +2 more
core   +1 more source