Results 21 to 30 of about 6,951,992 (282)

Subclonal reconstruction of tumors using machine learning and population genetics

Nature Genetics, 2020
Most cancer genomic data are generated from bulk samples composed of mixtures of cancer subpopulations, as well as normal cells. Subclonal reconstruction methods based on machine learning aim to separate those subpopulations in a sample and infer their ...
G. Caravagna, Timon Heide, Marc J. Williams, L. Zapata, D. Nichol, K. Chkhaidze, W. Cross, George D. Cresswell, B. Werner, A. Acar, L. Chesler, Chris P. Barnes, G. Sanguinetti, T. Graham, A. Sottoriva   +14 more
semanticscholar   +1 more source

Spatial Population Genetics: It's About Time [PDF]

Annual Review of Ecology, Evolution and Systematics, 2019
Many important questions about the history and dynamics of organisms have a geographical component: How many are there, and where do they live? How do they move and interbreed across the landscape?
Gideon S. Bradburd, Peter L. Ralph
semanticscholar   +1 more source

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications, 2020
Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang, Emma Pierce-Hoffman, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier, Andrew J. Hill, Anne H. O’Donnell-Luria, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Konrad J. Karczewski, Daniel G. MacArthur   +11 more
doaj   +1 more source

Mantel test in population genetics

Genetics and Molecular Biology, 2013
The comparison of genetic divergence or genetic distances, estimated by pairwise F ST and related statistics, with geographical distances by Mantel test is one of the most popular approaches to evaluate spatial processes driving population structure ...
José Alexandre F. Diniz-Filho, Thannya N. Soares, Jacqueline S. Lima, Ricardo Dobrovolski, Victor Lemes Landeiro, Mariana Pires de Campos Telles, Thiago F. Rangel, Luis Mauricio Bini   +7 more
doaj   +1 more source

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Nature Communications, 2022
The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal, Minxian Wang, Marcus D. R. Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean J. Jurgens, Patrick T. Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S. Udler, Puneet Batra, Amit V. Khera   +15 more
doaj   +1 more source

Neutral genomic signatures of host-parasite coevolution

BMC Evolutionary Biology, 2019
Background Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the ...
Daniel živković, Sona John, Mélissa Verin, Wolfgang Stephan, Aurélien Tellier   +4 more
doaj   +1 more source

Population genetics of forest trees.

Silva Fennica, 1982
The publication comprises proceedings of a conference held in Helsinki in 1981. Forest tree populations are investigated for population genetic structure, mating systems, mechanisms of genetic adaptation and ecological adaptation.
Tigerstedt, P.
doaj   +1 more source

Transposon-induced epigenetic silencing in the X chromosome as a novel form of dmrt1 expression regulation during sex determination in the fighting fish

BMC Biology, 2022
Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl, Gen Hua Yue   +15 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source