Results 21 to 30 of about 7,457,933 (340)

Archetypal Analysis for population genetics.

PLoS Computational Biology, 2022
The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse ...
Julia Gimbernat-Mayol, Albert Dominguez Mantes, Carlos D Bustamante, Daniel Mas Montserrat, Alexander G Ioannidis   +4 more
doaj   +1 more source

Diferenciación genética de tres poblaciones colombianas de Triatoma dimidiata (Latreille, 1811) mediante análisis molecular del gen mitocondrial ND4

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Triatoma dimidiata es el segundo vector más importante de la enfermedad de Chagas en Colombia, después de Rhodnius prolixus. El conocimiento de la composición genética y la diferenciación de poblaciones es fundamental para el adecuado ...
Nelson Grisales, Omar Triana, Víctor Angulo, Nicolás Jaramillo, Gabriel Parra-Henao, Francisco Panzera, Andrés Gómez-Palacio   +6 more
doaj   +1 more source

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications, 2020
Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang, Emma Pierce-Hoffman, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier, Andrew J. Hill, Anne H. O’Donnell-Luria, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Konrad J. Karczewski, Daniel G. MacArthur   +11 more
doaj   +1 more source

The population genetics of dN/dS. [PDF]

PLoS Genetics, 2008
Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which ...
Sergey Kryazhimskiy, Joshua B Plotkin
doaj   +1 more source

Pedigree Analysis: A Team-Based Learning Activity

MedEdPORTAL, 2017
Introduction Regardless of their specialty, physicians, particularly those practicing primary care in rural areas, typically encounter genetic conditions.
Jack Thatcher, Patty Canfield, Laurie Bauer, Brian N. Griffith   +3 more
doaj   +1 more source

The wild tomato species Solanum chilense shows variation in pathogen resistance between geographically distinct populations [PDF]

PeerJ, 2017
Wild tomatoes are a valuable source of disease resistance germplasm for tomato (Solanum lycopersicum) breeders. Many species are known to possess a certain degree of resistance against certain pathogens; however, evolution of resistance traits is yet ...
Remco Stam, Daniela Scheikl, Aurélien Tellier   +2 more
doaj   +2 more sources

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

Population Genetics and Pharmacogenetics [PDF]

, 2007
Genome-wide association studies (GWAS) have been hugely successful in identifying thousands of genetic loci robustly associated with hundreds of disease and other human traits. Since the first GWAS publication in an endocrinology-related topic, obesity in 2007, these studies have very rapidly increased in size and productivity. In 2011, this chapter is
Ken K. Ong, Cathy Elks
openaire   +6 more sources

Growth, competition and cooperation in spatial population genetics [PDF]

, 2012
We study an individual based model describing competition in space between two different alleles. Although the model is similar in spirit to classic models of spatial population genetics such as the stepping stone model, here however space is continuous ...
Allstadt, Barton, Benzi, Berti, Birch, Cencini, Crow, D.R. Nelson, Doering, D’Ovidio, F. Toschi, Fisher, Frey, Gardiner, Hallatschek, Hernandez-Garcia, Kimura, Kimura, Kolmogorov, Korolev, Korolev, Korolev, Law, M.H. Jensen, Neufeld, Neuhauser, Odor, O’Malley, O’Malley, P. Perlekar, Perlekar, Perlekar, Pigolotti, Pringle, R. Benzi, Risken, S. Pigolotti, Smith, Tel, Vlad, Wright   +40 more
core   +3 more sources

Population Genetics and Pharmacogenetics [PDF]

, 2005
The highlight for 2005/6 in population genetics was undoubtedly the publication of HapMap, a freely available public resource nearly of all common (>5% minor allele frequency) genetic differences in humans. Compared to the estimated 10 million single nucleotide polymorphisms (SNP) that we all share, at the launch of HapMap in 2002 there were fewer than
Heude, Barbara, Ong, Ken
openaire   +3 more sources