Results 31 to 40 of about 12,898 (182)

Missed opportunities for integrated testing of HIV and tuberculosis on the GeneXpert platform in Lesotho

African Journal of Laboratory Medicine, 2023
Background: Integrated testing, treatment and care are key strategies for addressing the dual burdens of tuberculosis and HIV. The GeneXpert instrument allows simultaneous HIV and tuberculosis testing, but its utilisation for integrated testing remains ...
Gamuchirai P. Gwaza, Monkoe Leqheka, Tsietso Mots’oane, Sabine Dittrich, Kekeletso Kao   +4 more
doaj   +1 more source

Evaluation of the Cepheid GeneXpert BCR-ABL Assay [PDF]

The Journal of Molecular Diagnostics, 2007
Patients with chronic myeloid leukemia harbor the chromosomal translocation t(9;22), which corresponds to fusion of the BCR and ABL genes at the DNA level. The translated fusion product is an oncogenic protein with increased ABL tyrosine kinase activity causing cell transformation.
Zsolt, Jobbagy, Reuel, van Atta, Kathleen M, Murphy, James R, Eshleman, Christopher D, Gocke   +4 more
openaire   +2 more sources

GeneXpert in the diagnosis of smear-negative PTB

African Health Sciences, 2014
No Abstract.
Joob, B, Wiwanitkit, V
openaire   +4 more sources

Evaluation of GeneXpert MTB/RIF for Diagnosis of Tuberculous Meningitis [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Microbiological confirmation is rare, and treatment is often delayed, increasing mortality and morbidity. The GeneXpert MTB/RIF test was evaluated in a large cohort of patients with suspected tuberculous meningitis.
Nguyen Thi Quynh Nhu, Dorothee Heemskerk, Do Dang Anh Thu, Tran Thi Hong Chau, Nguyen Thi Hoang, Ho Dang Trung Nghia, Pham Phu Loc, Đặng Thị Minh Hà, Laura Merson, Tran Thi Van Thinh, Jeremy Day, Nguyễn Văn Vĩnh Châu, Marcel Wolbers, Jeremy Farrar, Maxine Caws   +14 more
openaire   +4 more sources

Diagnostic concordance of GeneXpert HCV VL fingerstick and GeneXpert HCV viral load with RT-PCR in POCT settings among hemodialysis patients. [PDF]

PLoS One
Background Hepatitis C virus (HCV) remains a significant global health concern, particularly among high-risk populations such as patients undergoing hemodialysis. Although nucleic acid testing (NAT) using RT-PCR remains the gold standard for HCV RNA detection, its centralized laboratory workflow limits ...
Sulaiman AS, Nugroho P, Bahri DR, Rachmani D.   +3 more
europepmc   +3 more sources

Field evaluation of the Cepheid GeneXpert Chlamydia trachomatis assay for detection of infection in a trachoma endemic community in Tanzania. [PDF]

PLoS Neglected Tropical Diseases, 2013
To determine the sensitivity, specificity, and field utility of the Cepheid GeneXpert Chlamydia trachomatis (CT) Assay (GeneXpert) for ocular chlamydia infection compared to Roche Amplicor CT assay (Amplicor).In a trachoma-endemic community in Kongwa ...
Alexander Jenson, Laura Dize, Harran Mkocha, Beatriz Munoz, Jennifer Lee, Charlotte Gaydos, Thomas Quinn, Sheila K West   +7 more
doaj   +1 more source

GeneXpert MTB/RIF and GeneXpert MTB/RIF ultra in tuberculosis diagnosis: A comparative evaluation

Tuberk Toraks
Recent studies have shown that Gene Xpert MTB/RIF (Xpert) and Gene Xpert MTB/RIF ultra (Xpert-U) tests outperform traditional microbiological methods in detecting tuberculosis (TB) and identifying rifampicin resistance. This research aimed to examine their diagnostic accuracy and clinical relevance.This retrospective cohort study included patients aged
İhsan TOPALOĞLU, Yelda VAROL, Can BİÇMEN, Onur KARAMAN, Serir AKTOĞU ÖZKAN   +4 more
openaire   +2 more sources

Public investments in the development of GeneXpert molecular diagnostic technology

PLOS ONE, 2021
Background The GeneXpert diagnostic platform from the US based company Cepheid is an automated molecular diagnostic device that performs sample preparation and pathogen detection within a single cartridge-based assay. GeneXpert devices can enable diagnosis at the district level without the need for fully equipped clinical laboratories, are simple to ...
Dzintars Gotham, Lindsay McKenna, Stijn Deborggraeve, Suraj Madoori, David Branigan   +4 more
openaire   +4 more sources

Follow‐Up and Outcomes After Thermal Ablation Treatment Among HIV‐Infected Women From Resource‐Limited Countries With Positive HPV‐Based Screening: Results of the AIMA‐CC Cohort (ANRS 12375)

International Journal of Cancer, EarlyView.
ABSTRACT Primary screening for human papillomavirus (HPV) followed by treatment with thermal ablation (TA) is an important component of the global strategy to eliminate cervical cancer. However, evidence on post‐TA outcomes in women living with HIV (WLWH) remains limited.
Pierre Debeaudrap, Firmin Nongodo Kabore, Limsreng Setha, Joseph Tegbe, Brahima Doukoure, Moeung Sotheara, Olivier Segeral, Korn Aun, Eugène Messou, Matthieu Chicaud, Kim Sothea, Pierre Vassilakos, Armel Poda, Evelyne Kasilé Poda, Antoine Jaquet, Adolphe Some, Patrick Petignat, Gary Clifford, Apollinaire Horo   +18 more
wiley   +1 more source

Applying a Standardized Approach to Strengthen Performances of GeneXpert Networks programme: lessons learned from Burkina Faso, 2019

ERJ Open Research, 2020
GeneXpert scale-up is a historic step in the process of tuberculosis (TB) elimination. However, the global roll-out of the test has highlighted gaps that have limited its impact on the TB care cascade.
Riccardo Alagna, T. Léon Sawadogo, Elisa Tagliani, Adjima Combary, Daniela Maria Cirillo   +4 more
doaj   +1 more source